---
res:
  bibo_abstract:
  - In Gram negative bacteria, the multiple antibiotic resistance or mar operon, is
    known to control the expression of multi-drug efflux genes that protect bacteria
    from a wide range of drugs. As many different chemical compounds can induce this
    operon, identifying the parameters that govern the dynamics of its induction is
    crucial to better characterize the processes of tolerance and resistance. Most
    experiments have assumed that the properties of the mar transcriptional network
    can be inferred from population measurements. However, measurements from an asynchronous
    population of cells can mask underlying phenotypic variations of single cells.
    We monitored the activity of the mar promoter in single Escherichia coli cells
    in linear micro-colonies and established that the response to a steady level of
    inducer was most heterogeneous within individual colonies for an intermediate
    value of inducer. Specifically, sub-lineages defined by contiguous daughter-cells
    exhibited similar promoter activity, whereas activity was greatly variable between
    different sub-lineages. Specific sub-trees of uniform promoter activity persisted
    over several generations. Statistical analyses of the lineages suggest that the
    presence of these sub-trees is the signature of an inducible memory of the promoter
    state that is transmitted from mother to daughter cells. This single-cell study
    reveals that the degree of epigenetic inheritance changes as a function of inducer
    concentration, suggesting that phenotypic inheritance may be an inducible phenotype.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Calin C
      foaf_name: Guet, Calin C
      foaf_surname: Guet
      foaf_workInfoHomepage: http://www.librecat.org/personId=47F8433E-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0001-6220-2052
  - foaf_Person:
      foaf_givenName: L
      foaf_name: Bruneaux, L
      foaf_surname: Bruneaux
  - foaf_Person:
      foaf_givenName: P
      foaf_name: Oikonomou, P
      foaf_surname: Oikonomou
  - foaf_Person:
      foaf_givenName: M
      foaf_name: Aldana, M
      foaf_surname: Aldana
  - foaf_Person:
      foaf_givenName: P
      foaf_name: Cluzel, P
      foaf_surname: Cluzel
  bibo_doi: 10.3389/fmicb.2023.1049255
  bibo_volume: 14
  dct_date: 2023^xs_gYear
  dct_identifier:
  - UT:001030002600001
  dct_isPartOf:
  - http://id.crossref.org/issn/1664-302X
  dct_language: eng
  dct_publisher: Frontiers@
  dct_title: Monitoring lineages of growing and dividing bacteria reveals an inducible
    memory of <i>mar</i> operon expression@
  fabio_hasPubmedId: '37485524'
...