---
res:
  bibo_abstract:
  - In bacteria, replicative aging manifests as a difference in growth or survival
    between the two cells emerging from division. One cell can be regarded as an aging
    mother with a decreased potential for future survival and division, the other
    as a rejuvenated daughter. Here, we aimed at investigating some of the processes
    involved in aging in the bacterium Escherichia coli, where the two types of cells
    can be distinguished by the age of their cell poles. We found that certain changes
    in the regulation of the carbohydrate metabolism can affect aging. A mutation
    in the carbon storage regulator gene, csrA, leads to a dramatically shorter replicative
    lifespan; csrA mutants stop dividing once their pole exceeds an age of about five
    divisions. These old-pole cells accumulate glycogen at their old cell poles; after
    their last division, they do not contain a chromosome, presumably because of spatial
    exclusion by the glycogen aggregates. The new-pole daughters produced by these
    aging mothers are born young; they only express the deleterious phenotype once
    their pole is old. These results demonstrate how manipulations of nutrient allocation
    can lead to the exclusion of the chromosome and limit replicative lifespan in
    E. coli, and illustrate how mutations can have phenotypic effects that are specific
    for cells with old poles. This raises the question how bacteria can avoid the
    accumulation of such mutations in their genomes over evolutionary times, and how
    they can achieve the long replicative lifespans that have recently been reported.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Alex
      foaf_name: Boehm, Alex
      foaf_surname: Boehm
  - foaf_Person:
      foaf_givenName: Markus
      foaf_name: Arnoldini, Markus
      foaf_surname: Arnoldini
  - foaf_Person:
      foaf_givenName: Tobias
      foaf_name: Bergmiller, Tobias
      foaf_surname: Bergmiller
      foaf_workInfoHomepage: http://www.librecat.org/personId=2C471CFA-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0001-5396-4346
  - foaf_Person:
      foaf_givenName: Thomas
      foaf_name: Röösli, Thomas
      foaf_surname: Röösli
  - foaf_Person:
      foaf_givenName: Colette
      foaf_name: Bigosch, Colette
      foaf_surname: Bigosch
  - foaf_Person:
      foaf_givenName: Martin
      foaf_name: Ackermann, Martin
      foaf_surname: Ackermann
  bibo_doi: 10.1371/journal.pgen.1005974
  bibo_issue: '4'
  bibo_volume: 12
  dct_date: 2016^xs_gYear
  dct_identifier:
  - UT:000375231900025
  dct_language: eng
  dct_publisher: Public Library of Science@
  dct_title: Genetic manipulation of glycogen allocation affects replicative lifespan
    in E coli@
...