--- _id: '12531' abstract: - lang: eng text: "All visual experiences of the vertebrates begin with light being converted into electrical signals\r\nby the eye retina. Retinal ganglion cells (RGCs) are the neurons of the innermost layer of the\r\nmammal retina, and they transmit visual information to the rest of the brain.\r\nIt has been shown that RGCs vary in their morphology and genetic profiles, moreover they can\r\nbe unambiguously grouped into subtypes that share the same morphological and/or molecular\r\nproperties. However, in terms of RGCs function, it remains unclear how many distinct types\r\nthere are and what response properties their typology relies on. Even given the recent studies\r\nthat successfully classified RGCs in a patch of the retina [1] and in scotopic conditions [2], the\r\nquestion remains whether the found subtypes persist across the entire retina.\r\nIn this work, using a novel imaging method, we show that, when sampled from a large portion\r\nof the retina, RGCs can not be clearly divided into functional subtypes. We found that in\r\nphotopic conditions, which implies more prominent natural scene statistic differences across\r\nthe visual field, response properties can be exhibited by cells differently depending on their\r\nlocation in the retina, which leads to formation of a gradient of features rather than distinct\r\nclasses.\r\nThis finding suggests that RGCs follow a global organization across the visual field of the\r\nanimal, adapting each RGC subtype to the requirements imposed by the natural scene statistics." alternative_title: - ISTA Master's Thesis article_processing_charge: No author: - first_name: Kseniia full_name: Kirillova, Kseniia id: 8e3f931e-dc85-11ea-9058-e7b957bf23f0 last_name: Kirillova citation: ama: Kirillova K. Panoramic functional gradients across the mouse retina. 2023. doi:10.15479/at:ista:12531 apa: Kirillova, K. (2023). Panoramic functional gradients across the mouse retina. Institute of Science and Technology Austria. https://doi.org/10.15479/at:ista:12531 chicago: Kirillova, Kseniia. “Panoramic Functional Gradients across the Mouse Retina.” Institute of Science and Technology Austria, 2023. https://doi.org/10.15479/at:ista:12531. ieee: K. Kirillova, “Panoramic functional gradients across the mouse retina,” Institute of Science and Technology Austria, 2023. ista: Kirillova K. 2023. Panoramic functional gradients across the mouse retina. Institute of Science and Technology Austria. mla: Kirillova, Kseniia. Panoramic Functional Gradients across the Mouse Retina. Institute of Science and Technology Austria, 2023, doi:10.15479/at:ista:12531. short: K. Kirillova, Panoramic Functional Gradients across the Mouse Retina, Institute of Science and Technology Austria, 2023. date_created: 2023-02-09T07:45:05Z date_published: 2023-02-08T00:00:00Z date_updated: 2024-02-09T23:30:04Z day: '08' ddc: - '570' degree_awarded: MS department: - _id: GradSch - _id: MaJö doi: 10.15479/at:ista:12531 file: - access_level: open_access checksum: 57d8da3a6c749eb1556b7435fe266a5f content_type: application/pdf creator: cchlebak date_created: 2023-02-09T08:03:32Z date_updated: 2024-02-09T23:30:03Z embargo: 2024-02-08 file_id: '12532' file_name: Thesis_Kseniia___ISTA__istaustriathesis_PDF-A.pdf file_size: 8369317 relation: main_file - access_level: closed checksum: 87fb44318e4f9eb9da2ad9ad6ca8e76f content_type: application/x-zip-compressed creator: cchlebak date_created: 2023-02-10T09:32:06Z date_updated: 2024-02-09T23:30:03Z embargo_to: open_access file_id: '12535' file_name: Thesis Kseniia - ISTA [istaustriathesis]-FINAL.zip file_size: 11204408 relation: source_file file_date_updated: 2024-02-09T23:30:03Z has_accepted_license: '1' language: - iso: eng license: https://creativecommons.org/licenses/by-nc-sa/4.0/ month: '02' oa: 1 oa_version: Published Version page: '46' publication_identifier: issn: - 2791-4585 publication_status: published publisher: Institute of Science and Technology Austria status: public supervisor: - first_name: Maximilian A full_name: Jösch, Maximilian A id: 2BD278E6-F248-11E8-B48F-1D18A9856A87 last_name: Jösch orcid: 0000-0002-3937-1330 title: Panoramic functional gradients across the mouse retina tmp: image: /images/cc_by_nc_sa.png legal_code_url: https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode name: Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) short: CC BY-NC-SA (4.0) type: dissertation user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1 year: '2023' ...