{"day":"01","scopus_import":1,"publist_id":"6070","intvolume":"         3","has_accepted_license":"1","pubrep_id":"704","date_published":"2016-04-01T00:00:00Z","tmp":{"short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png"},"quality_controlled":"1","type":"journal_article","acknowledgement":"We thank Dietmar Schmucker for reading a draft of this manuscript and thank him and his group for\r\nhelpful discussions. We thank Barbara Hasert, Kevin Ferro and Manuel F. Talarico for technical support and helpful\r\ndiscussions. We also thank two anonymous reviewers for their comments. This study was supported by grants from the Volkswagen Stiftung (1/83 516 and AZ 86020: both to S.A.O.A.) and from the DFG priority programme 1399 ‘Host parasite coevolution’ (KU 1929/4-2 to R.P. and J.K.).","oa":1,"issue":"4","date_updated":"2021-01-12T06:49:25Z","author":[{"last_name":"Peuß","full_name":"Peuß, Robert","first_name":"Robert"},{"last_name":"Wensing","first_name":"Kristina","full_name":"Wensing, Kristina"},{"last_name":"Woestmann","full_name":"Woestmann, Luisa","first_name":"Luisa"},{"last_name":"Eggert","full_name":"Eggert, Hendrik","first_name":"Hendrik"},{"orcid":"0000-0002-8214-4758","full_name":"Milutinovic, Barbara","first_name":"Barbara","id":"2CDC32B8-F248-11E8-B48F-1D18A9856A87","last_name":"Milutinovic"},{"first_name":"Marlene","full_name":"Sroka, Marlene","last_name":"Sroka"},{"first_name":"Jörn","full_name":"Scharsack, Jörn","last_name":"Scharsack"},{"full_name":"Kurtz, Joachim","first_name":"Joachim","last_name":"Kurtz"},{"full_name":"Armitage, Sophie","first_name":"Sophie","last_name":"Armitage"}],"date_created":"2018-12-11T11:50:58Z","language":[{"iso":"eng"}],"citation":{"ama":"Peuß R, Wensing K, Woestmann L, et al. Down syndrome cell adhesion molecule 1: Testing for a role in insect immunity, behaviour and reproduction. <i>Royal Society Open Science</i>. 2016;3(4). doi:<a href=\"https://doi.org/10.1098/rsos.160138\">10.1098/rsos.160138</a>","mla":"Peuß, Robert, et al. “Down Syndrome Cell Adhesion Molecule 1: Testing for a Role in Insect Immunity, Behaviour and Reproduction.” <i>Royal Society Open Science</i>, vol. 3, no. 4, 160138, Royal Society, The, 2016, doi:<a href=\"https://doi.org/10.1098/rsos.160138\">10.1098/rsos.160138</a>.","short":"R. Peuß, K. Wensing, L. Woestmann, H. Eggert, B. Milutinovic, M. Sroka, J. Scharsack, J. Kurtz, S. Armitage, Royal Society Open Science 3 (2016).","apa":"Peuß, R., Wensing, K., Woestmann, L., Eggert, H., Milutinovic, B., Sroka, M., … Armitage, S. (2016). Down syndrome cell adhesion molecule 1: Testing for a role in insect immunity, behaviour and reproduction. <i>Royal Society Open Science</i>. Royal Society, The. <a href=\"https://doi.org/10.1098/rsos.160138\">https://doi.org/10.1098/rsos.160138</a>","ieee":"R. Peuß <i>et al.</i>, “Down syndrome cell adhesion molecule 1: Testing for a role in insect immunity, behaviour and reproduction,” <i>Royal Society Open Science</i>, vol. 3, no. 4. Royal Society, The, 2016.","ista":"Peuß R, Wensing K, Woestmann L, Eggert H, Milutinovic B, Sroka M, Scharsack J, Kurtz J, Armitage S. 2016. Down syndrome cell adhesion molecule 1: Testing for a role in insect immunity, behaviour and reproduction. Royal Society Open Science. 3(4), 160138.","chicago":"Peuß, Robert, Kristina Wensing, Luisa Woestmann, Hendrik Eggert, Barbara Milutinovic, Marlene Sroka, Jörn Scharsack, Joachim Kurtz, and Sophie Armitage. “Down Syndrome Cell Adhesion Molecule 1: Testing for a Role in Insect Immunity, Behaviour and Reproduction.” <i>Royal Society Open Science</i>. Royal Society, The, 2016. <a href=\"https://doi.org/10.1098/rsos.160138\">https://doi.org/10.1098/rsos.160138</a>."},"publication_status":"published","publisher":"Royal Society, The","user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","ddc":["576","592"],"file_date_updated":"2020-07-14T12:44:41Z","file":[{"content_type":"application/pdf","checksum":"c3cd84666c8dc0ce6a784f1c82c1cf68","access_level":"open_access","creator":"system","file_id":"5049","date_updated":"2020-07-14T12:44:41Z","date_created":"2018-12-12T10:14:01Z","file_name":"IST-2016-704-v1+1_160138.full.pdf","relation":"main_file","file_size":627377}],"article_number":"160138","volume":3,"month":"04","_id":"1255","year":"2016","abstract":[{"text":"Down syndrome cell adhesion molecule 1 (Dscam1) has widereaching and vital neuronal functions although the role it plays in insect and crustacean immunity is less well understood. In this study, we combine different approaches to understand the roles that Dscam1 plays in fitness-related contexts in two model insect species. Contrary to our expectations, we found no short-term modulation of Dscam1 gene expression after haemocoelic or oral bacterial exposure in Tribolium castaneum, or after haemocoelic bacterial exposure in Drosophila melanogaster. Furthermore, RNAi-mediated Dscam1 knockdown and subsequent bacterial exposure did not reduce T. castaneum survival. However, Dscam1 knockdown in larvae resulted in adult locomotion defects, as well as dramatically reduced fecundity in males and females. We suggest that Dscam1 does not always play a straightforward role in immunity, but strongly influences behaviour and fecundity. This study takes a step towards understanding more about the role of this intriguing gene from different phenotypic perspectives.","lang":"eng"}],"title":"Down syndrome cell adhesion molecule 1: Testing for a role in insect immunity, behaviour and reproduction","department":[{"_id":"SyCr"}],"publication":"Royal Society Open Science","status":"public","doi":"10.1098/rsos.160138","oa_version":"Published Version"}