---
_id: '1255'
abstract:
- lang: eng
text: Down syndrome cell adhesion molecule 1 (Dscam1) has widereaching and vital
neuronal functions although the role it plays in insect and crustacean immunity
is less well understood. In this study, we combine different approaches to understand
the roles that Dscam1 plays in fitness-related contexts in two model insect species.
Contrary to our expectations, we found no short-term modulation of Dscam1 gene
expression after haemocoelic or oral bacterial exposure in Tribolium castaneum,
or after haemocoelic bacterial exposure in Drosophila melanogaster. Furthermore,
RNAi-mediated Dscam1 knockdown and subsequent bacterial exposure did not reduce
T. castaneum survival. However, Dscam1 knockdown in larvae resulted in adult locomotion
defects, as well as dramatically reduced fecundity in males and females. We suggest
that Dscam1 does not always play a straightforward role in immunity, but strongly
influences behaviour and fecundity. This study takes a step towards understanding
more about the role of this intriguing gene from different phenotypic perspectives.
acknowledgement: "We thank Dietmar Schmucker for reading a draft of this manuscript
and thank him and his group for\r\nhelpful discussions. We thank Barbara Hasert,
Kevin Ferro and Manuel F. Talarico for technical support and helpful\r\ndiscussions.
We also thank two anonymous reviewers for their comments. This study was supported
by grants from the Volkswagen Stiftung (1/83 516 and AZ 86020: both to S.A.O.A.)
and from the DFG priority programme 1399 ‘Host parasite coevolution’ (KU 1929/4-2
to R.P. and J.K.)."
article_number: '160138'
author:
- first_name: Robert
full_name: Peuß, Robert
last_name: Peuß
- first_name: Kristina
full_name: Wensing, Kristina
last_name: Wensing
- first_name: Luisa
full_name: Woestmann, Luisa
last_name: Woestmann
- first_name: Hendrik
full_name: Eggert, Hendrik
last_name: Eggert
- first_name: Barbara
full_name: Milutinovic, Barbara
id: 2CDC32B8-F248-11E8-B48F-1D18A9856A87
last_name: Milutinovic
orcid: 0000-0002-8214-4758
- first_name: Marlene
full_name: Sroka, Marlene
last_name: Sroka
- first_name: Jörn
full_name: Scharsack, Jörn
last_name: Scharsack
- first_name: Joachim
full_name: Kurtz, Joachim
last_name: Kurtz
- first_name: Sophie
full_name: Armitage, Sophie
last_name: Armitage
citation:
ama: 'Peuß R, Wensing K, Woestmann L, et al. Down syndrome cell adhesion molecule
1: Testing for a role in insect immunity, behaviour and reproduction. Royal
Society Open Science. 2016;3(4). doi:10.1098/rsos.160138'
apa: 'Peuß, R., Wensing, K., Woestmann, L., Eggert, H., Milutinovic, B., Sroka,
M., … Armitage, S. (2016). Down syndrome cell adhesion molecule 1: Testing for
a role in insect immunity, behaviour and reproduction. Royal Society Open Science.
Royal Society, The. https://doi.org/10.1098/rsos.160138'
chicago: 'Peuß, Robert, Kristina Wensing, Luisa Woestmann, Hendrik Eggert, Barbara
Milutinovic, Marlene Sroka, Jörn Scharsack, Joachim Kurtz, and Sophie Armitage.
“Down Syndrome Cell Adhesion Molecule 1: Testing for a Role in Insect Immunity,
Behaviour and Reproduction.” Royal Society Open Science. Royal Society,
The, 2016. https://doi.org/10.1098/rsos.160138.'
ieee: 'R. Peuß et al., “Down syndrome cell adhesion molecule 1: Testing for
a role in insect immunity, behaviour and reproduction,” Royal Society Open
Science, vol. 3, no. 4. Royal Society, The, 2016.'
ista: 'Peuß R, Wensing K, Woestmann L, Eggert H, Milutinovic B, Sroka M, Scharsack
J, Kurtz J, Armitage S. 2016. Down syndrome cell adhesion molecule 1: Testing
for a role in insect immunity, behaviour and reproduction. Royal Society Open
Science. 3(4), 160138.'
mla: 'Peuß, Robert, et al. “Down Syndrome Cell Adhesion Molecule 1: Testing for
a Role in Insect Immunity, Behaviour and Reproduction.” Royal Society Open
Science, vol. 3, no. 4, 160138, Royal Society, The, 2016, doi:10.1098/rsos.160138.'
short: R. Peuß, K. Wensing, L. Woestmann, H. Eggert, B. Milutinovic, M. Sroka, J.
Scharsack, J. Kurtz, S. Armitage, Royal Society Open Science 3 (2016).
date_created: 2018-12-11T11:50:58Z
date_published: 2016-04-01T00:00:00Z
date_updated: 2021-01-12T06:49:25Z
day: '01'
ddc:
- '576'
- '592'
department:
- _id: SyCr
doi: 10.1098/rsos.160138
file:
- access_level: open_access
checksum: c3cd84666c8dc0ce6a784f1c82c1cf68
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:14:01Z
date_updated: 2020-07-14T12:44:41Z
file_id: '5049'
file_name: IST-2016-704-v1+1_160138.full.pdf
file_size: 627377
relation: main_file
file_date_updated: 2020-07-14T12:44:41Z
has_accepted_license: '1'
intvolume: ' 3'
issue: '4'
language:
- iso: eng
license: https://creativecommons.org/licenses/by/4.0/
month: '04'
oa: 1
oa_version: Published Version
publication: Royal Society Open Science
publication_status: published
publisher: Royal Society, The
publist_id: '6070'
pubrep_id: '704'
quality_controlled: '1'
scopus_import: 1
status: public
title: 'Down syndrome cell adhesion molecule 1: Testing for a role in insect immunity,
behaviour and reproduction'
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 3
year: '2016'
...