---
res:
  bibo_abstract:
  - Presynaptic inputs determine the pattern of activation of postsynaptic neurons
    in a neural circuit. Molecular and genetic pathways that regulate the selective
    formation of subsets of presynaptic inputs are largely unknown, despite significant
    understanding of the general process of synaptogenesis. In this study, we have
    begun to identify such factors using the spinal monosynaptic stretch reflex circuit
    as a model system. In this neuronal circuit, Ia proprioceptive afferents establish
    monosynaptic connections with spinal motor neurons that project to the same muscle
    (termed homonymous connections) or muscles with related or synergistic function.
    However, monosynaptic connections are not formed with motor neurons innervating
    muscles with antagonistic functions. The ETS transcription factor ER81 (also known
    as ETV1) is expressed by all proprioceptive afferents, but only a small set of
    motor neuron pools in the lumbar spinal cord of the mouse. Here we use conditional
    mouse genetic techniques to eliminate Er81 expression selectively from motor neurons.
    We find that ablation of Er81 in motor neurons reduces synaptic inputs from proprioceptive
    afferents conveying information from homonymous and synergistic muscles, with
    no change observed in the connectivity pattern from antagonistic proprioceptive
    afferents. In summary, these findings suggest a role for ER81 in defined motor
    neuron pools to control the assembly of specific presynaptic inputs and thereby
    influence the profile of activation of these motor neurons.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: David R.
      foaf_name: Ladle, David R.
      foaf_surname: Ladle
  - foaf_Person:
      foaf_givenName: Simon
      foaf_name: Hippenmeyer, Simon
      foaf_surname: Hippenmeyer
      foaf_workInfoHomepage: http://www.librecat.org/personId=37B36620-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0003-2279-1061
  bibo_doi: 10.1152/jn.00172.2022
  bibo_issue: '3'
  bibo_volume: 129
  dct_date: 2023^xs_gYear
  dct_identifier:
  - UT:000957721600001
  dct_isPartOf:
  - http://id.crossref.org/issn/0022-3077
  - http://id.crossref.org/issn/1522-1598
  dct_language: eng
  dct_publisher: American Physiological Society@
  dct_subject:
  - Physiology
  - General Neuroscience
  dct_title: Loss of ETV1/ER81 in motor neurons leads to reduced monosynaptic inputs
    from proprioceptive sensory neurons@
  fabio_hasPubmedId: '36695533'
...