---
_id: '12562'
abstract:
- lang: eng
  text: Presynaptic inputs determine the pattern of activation of postsynaptic neurons
    in a neural circuit. Molecular and genetic pathways that regulate the selective
    formation of subsets of presynaptic inputs are largely unknown, despite significant
    understanding of the general process of synaptogenesis. In this study, we have
    begun to identify such factors using the spinal monosynaptic stretch reflex circuit
    as a model system. In this neuronal circuit, Ia proprioceptive afferents establish
    monosynaptic connections with spinal motor neurons that project to the same muscle
    (termed homonymous connections) or muscles with related or synergistic function.
    However, monosynaptic connections are not formed with motor neurons innervating
    muscles with antagonistic functions. The ETS transcription factor ER81 (also known
    as ETV1) is expressed by all proprioceptive afferents, but only a small set of
    motor neuron pools in the lumbar spinal cord of the mouse. Here we use conditional
    mouse genetic techniques to eliminate Er81 expression selectively from motor neurons.
    We find that ablation of Er81 in motor neurons reduces synaptic inputs from proprioceptive
    afferents conveying information from homonymous and synergistic muscles, with
    no change observed in the connectivity pattern from antagonistic proprioceptive
    afferents. In summary, these findings suggest a role for ER81 in defined motor
    neuron pools to control the assembly of specific presynaptic inputs and thereby
    influence the profile of activation of these motor neurons.
acknowledgement: The authors gratefully thank Dr. Silvia Arber, University of Basel
  and Friedrich Miescher Institute for Biomedical Research, for support and in whose
  lab the data were collected. For advice on statistical analysis, we thank Michael
  Bottomley from the Statistical Consulting Center, College of Science and Mathematics,
  Wright State University.
article_processing_charge: No
article_type: original
author:
- first_name: David R.
  full_name: Ladle, David R.
  last_name: Ladle
- first_name: Simon
  full_name: Hippenmeyer, Simon
  id: 37B36620-F248-11E8-B48F-1D18A9856A87
  last_name: Hippenmeyer
  orcid: 0000-0003-2279-1061
citation:
  ama: Ladle DR, Hippenmeyer S. Loss of ETV1/ER81 in motor neurons leads to reduced
    monosynaptic inputs from proprioceptive sensory neurons. <i>Journal of Neurophysiology</i>.
    2023;129(3):501-512. doi:<a href="https://doi.org/10.1152/jn.00172.2022">10.1152/jn.00172.2022</a>
  apa: Ladle, D. R., &#38; Hippenmeyer, S. (2023). Loss of ETV1/ER81 in motor neurons
    leads to reduced monosynaptic inputs from proprioceptive sensory neurons. <i>Journal
    of Neurophysiology</i>. American Physiological Society. <a href="https://doi.org/10.1152/jn.00172.2022">https://doi.org/10.1152/jn.00172.2022</a>
  chicago: Ladle, David R., and Simon Hippenmeyer. “Loss of ETV1/ER81 in Motor Neurons
    Leads to Reduced Monosynaptic Inputs from Proprioceptive Sensory Neurons.” <i>Journal
    of Neurophysiology</i>. American Physiological Society, 2023. <a href="https://doi.org/10.1152/jn.00172.2022">https://doi.org/10.1152/jn.00172.2022</a>.
  ieee: D. R. Ladle and S. Hippenmeyer, “Loss of ETV1/ER81 in motor neurons leads
    to reduced monosynaptic inputs from proprioceptive sensory neurons,” <i>Journal
    of Neurophysiology</i>, vol. 129, no. 3. American Physiological Society, pp. 501–512,
    2023.
  ista: Ladle DR, Hippenmeyer S. 2023. Loss of ETV1/ER81 in motor neurons leads to
    reduced monosynaptic inputs from proprioceptive sensory neurons. Journal of Neurophysiology.
    129(3), 501–512.
  mla: Ladle, David R., and Simon Hippenmeyer. “Loss of ETV1/ER81 in Motor Neurons
    Leads to Reduced Monosynaptic Inputs from Proprioceptive Sensory Neurons.” <i>Journal
    of Neurophysiology</i>, vol. 129, no. 3, American Physiological Society, 2023,
    pp. 501–12, doi:<a href="https://doi.org/10.1152/jn.00172.2022">10.1152/jn.00172.2022</a>.
  short: D.R. Ladle, S. Hippenmeyer, Journal of Neurophysiology 129 (2023) 501–512.
date_created: 2023-02-15T14:46:14Z
date_published: 2023-03-01T00:00:00Z
date_updated: 2024-10-21T06:01:28Z
day: '01'
department:
- _id: SiHi
doi: 10.1152/jn.00172.2022
external_id:
  isi:
  - '000957721600001'
  pmid:
  - '36695533'
fulldoi: https://doi.org/10.1152/jn.00172.2022
intvolume: '       129'
isi: 1
issue: '3'
keyword:
- Physiology
- General Neuroscience
language:
- iso: eng
month: '03'
oa_version: None
page: 501-512
pmid: 1
publication: Journal of Neurophysiology
publication_identifier:
  eissn:
  - 1522-1598
  issn:
  - 0022-3077
publication_status: published
publisher: American Physiological Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Loss of ETV1/ER81 in motor neurons leads to reduced monosynaptic inputs from
  proprioceptive sensory neurons
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 129
year: '2023'
...