---
res:
  bibo_abstract:
  - Sperm chromatin is typically transformed by protamines into a compact and transcriptionally
    inactive state1,2. Sperm cells of flowering plants lack protamines, yet they have
    small, transcriptionally active nuclei with chromatin condensed through an unknown
    mechanism3,4. Here we show that a histone variant, H2B.8, mediates sperm chromatin
    and nuclear condensation in Arabidopsis thaliana. Loss of H2B.8 causes enlarged
    sperm nuclei with dispersed chromatin, whereas ectopic expression in somatic cells
    produces smaller nuclei with aggregated chromatin. This result demonstrates that
    H2B.8 is sufficient for chromatin condensation. H2B.8 aggregates transcriptionally
    inactive AT-rich chromatin into phase-separated condensates, which facilitates
    nuclear compaction without reducing transcription. Reciprocal crosses show that
    mutation of h2b.8 reduces male transmission, which suggests that H2B.8-mediated
    sperm compaction is important for fertility. Altogether, our results reveal a
    new mechanism of nuclear compaction through global aggregation of unexpressed
    chromatin. We propose that H2B.8 is an evolutionary innovation of flowering plants
    that achieves nuclear condensation compatible with active transcription.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Toby
      foaf_name: Buttress, Toby
      foaf_surname: Buttress
  - foaf_Person:
      foaf_givenName: Shengbo
      foaf_name: He, Shengbo
      foaf_surname: He
  - foaf_Person:
      foaf_givenName: Liang
      foaf_name: Wang, Liang
      foaf_surname: Wang
  - foaf_Person:
      foaf_givenName: Shaoli
      foaf_name: Zhou, Shaoli
      foaf_surname: Zhou
  - foaf_Person:
      foaf_givenName: Gerhard
      foaf_name: Saalbach, Gerhard
      foaf_surname: Saalbach
  - foaf_Person:
      foaf_givenName: Martin
      foaf_name: Vickers, Martin
      foaf_surname: Vickers
  - foaf_Person:
      foaf_givenName: Guohong
      foaf_name: Li, Guohong
      foaf_surname: Li
  - foaf_Person:
      foaf_givenName: Pilong
      foaf_name: Li, Pilong
      foaf_surname: Li
  - foaf_Person:
      foaf_givenName: Xiaoqi
      foaf_name: Feng, Xiaoqi
      foaf_surname: Feng
      foaf_workInfoHomepage: http://www.librecat.org/personId=e0164712-22ee-11ed-b12a-d80fcdf35958
    orcid: 0000-0002-4008-1234
  bibo_doi: 10.1038/s41586-022-05386-6
  bibo_issue: '7936'
  bibo_volume: 611
  dct_date: 2022^xs_gYear
  dct_isPartOf:
  - http://id.crossref.org/issn/0028-0836
  - http://id.crossref.org/issn/1476-4687
  dct_language: eng
  dct_publisher: Springer Nature@
  dct_title: Histone H2B.8 compacts flowering plant sperm through chromatin phase
    separation@
  fabio_hasPubmedId: '36323776'
...