Curvature in biological systems: Its quantification, emergence, and implications across the scales

article Curvature in biological systems: Its quantification, emergence, and implications across the scales published yes Barbara Schamberger author Ricardo Ziege author Karine Anselme author Martine Ben Amar author Michał Bykowski author André P.G. Castro author Amaia Cipitria author Rhoslyn A. Coles author Rumiana Dimova author Michaela Eder author Sebastian Ehrig author Luis M. Escudero author Myfanwy E. Evans author Paulo R. Fernandes author Peter Fratzl author Liesbet Geris author Notburga Gierlinger author Edouard B Hannezo author 3A9DB764-F248-11E8-B48F-1D18A9856A870000-0001-6005-1561 Aleš Iglič author Jacob J.K. Kirkensgaard author Philip Kollmannsberger author Łucja Kowalewska author Nicholas A. Kurniawan author Ioannis Papantoniou author Laurent Pieuchot author Tiago H.V. Pires author Lars D. Renner author Andrew O. Sageman-Furnas author Gerd E. Schröder-Turk author Anupam Sengupta author Vikas R. Sharma author Antonio Tagua author Caterina Tomba author Xavier Trepat author Sarah L. Waters author Edwina F. Yeo author Andreas Roschger author Cécile M. Bidan author John W.C. Dunlop author EdHa department Surface curvature both emerges from, and influences the behavior of, living objects at length scales ranging from cell membranes to single cells to tissues and organs. The relevance of surface curvature in biology is supported by numerous experimental and theoretical investigations in recent years. In this review, first, a brief introduction to the key ideas of surface curvature in the context of biological systems is given and the challenges that arise when measuring surface curvature are discussed. Giving an overview of the emergence of curvature in biological systems, its significance at different length scales becomes apparent. On the other hand, summarizing current findings also shows that both single cells and entire cell sheets, tissues or organisms respond to curvature by modulating their shape and their migration behavior. Finally, the interplay between the distribution of morphogens or micro-organisms and the emergence of curvature across length scales is addressed with examples demonstrating these key mechanistic principles of morphogenesis. Overall, this review highlights that curved interfaces are not merely a passive by-product of the chemical, biological, and mechanical processes but that curvature acts also as a signal that co-determines these processes. https://research-explorer.ista.ac.at/download/12710/14373/2023_AdvancedMaterials_Schamberger.pdf application/pdfno Wiley2023 eng Advanced Materials 0935-9648 1521-4095 36461812 00094106890000110.1002/adma.202206110 3513 B. Schamberger et al., “Curvature in biological systems: Its quantification, emergence, and implications across the scales,” Advanced Materials, vol. 35, no. 13. Wiley, 2023. B. Schamberger, R. Ziege, K. Anselme, M. Ben Amar, M. Bykowski, A.P.G. Castro, A. Cipitria, R.A. Coles, R. Dimova, M. Eder, S. Ehrig, L.M. Escudero, M.E. Evans, P.R. Fernandes, P. Fratzl, L. Geris, N. Gierlinger, E.B. Hannezo, A. Iglič, J.J.K. Kirkensgaard, P. Kollmannsberger, Ł. Kowalewska, N.A. Kurniawan, I. Papantoniou, L. Pieuchot, T.H.V. Pires, L.D. Renner, A.O. Sageman-Furnas, G.E. Schröder-Turk, A. Sengupta, V.R. Sharma, A. Tagua, C. Tomba, X. Trepat, S.L. Waters, E.F. Yeo, A. Roschger, C.M. Bidan, J.W.C. Dunlop, Advanced Materials 35 (2023). Schamberger, B., Ziege, R., Anselme, K., Ben Amar, M., Bykowski, M., Castro, A. P. G., … Dunlop, J. W. C. (2023). Curvature in biological systems: Its quantification, emergence, and implications across the scales. Advanced Materials. Wiley. <a href="https://doi.org/10.1002/adma.202206110">https://doi.org/10.1002/adma.202206110</a> Schamberger, Barbara, et al. “Curvature in Biological Systems: Its Quantification, Emergence, and Implications across the Scales.” Advanced Materials, vol. 35, no. 13, 2206110, Wiley, 2023, doi:<a href="https://doi.org/10.1002/adma.202206110">10.1002/adma.202206110</a>. Schamberger, Barbara, Ricardo Ziege, Karine Anselme, Martine Ben Amar, Michał Bykowski, André P.G. Castro, Amaia Cipitria, et al. “Curvature in Biological Systems: Its Quantification, Emergence, and Implications across the Scales.” Advanced Materials. Wiley, 2023. <a href="https://doi.org/10.1002/adma.202206110">https://doi.org/10.1002/adma.202206110</a>. Schamberger B, Ziege R, Anselme K, et al. Curvature in biological systems: Its quantification, emergence, and implications across the scales. Advanced Materials. 2023;35(13). doi:<a href="https://doi.org/10.1002/adma.202206110">10.1002/adma.202206110</a> Schamberger B, Ziege R, Anselme K, Ben Amar M, Bykowski M, Castro APG, Cipitria A, Coles RA, Dimova R, Eder M, Ehrig S, Escudero LM, Evans ME, Fernandes PR, Fratzl P, Geris L, Gierlinger N, Hannezo EB, Iglič A, Kirkensgaard JJK, Kollmannsberger P, Kowalewska Ł, Kurniawan NA, Papantoniou I, Pieuchot L, Pires THV, Renner LD, Sageman-Furnas AO, Schröder-Turk GE, Sengupta A, Sharma VR, Tagua A, Tomba C, Trepat X, Waters SL, Yeo EF, Roschger A, Bidan CM, Dunlop JWC. 2023. Curvature in biological systems: Its quantification, emergence, and implications across the scales. Advanced Materials. 35(13), 2206110. 127102023-03-05T23:01:06Z2023-09-26T10:56:46Z