article published yes Krisztián Kovács author 2AB5821E-F248-11E8-B48F-1D18A9856A87 Joseph O'Neill author 426376DC-F248-11E8-B48F-1D18A9856A87 Philipp Schönenberger author 3B9D816C-F248-11E8-B48F-1D18A9856A87 Markku Penttonen author Dámaris K Rangel Guerrero author 4871BCE6-F248-11E8-B48F-1D18A9856A870000-0002-8602-4374 Jozsef L Csicsvari author 3FA14672-F248-11E8-B48F-1D18A9856A870000-0002-5193-4036 JoCs department International IST Postdoc Fellowship Programme project Memory-related information processing in neuronal circuits of the hippocampus and entorhinal cortex project During hippocampal sharp wave/ripple (SWR) events, previously occurring, sensory inputdriven neuronal firing patterns are replayed. Such replay is thought to be important for plasticity- related processes and consolidation of memory traces. It has previously been shown that the electrical stimulation-induced disruption of SWR events interferes with learning in rodents in different experimental paradigms. On the other hand, the cognitive map theory posits that the plastic changes of the firing of hippocampal place cells constitute the electrophysiological counterpart of the spatial learning, observable at the behavioral level. Therefore, we tested whether intact SWR events occurring during the sleep/rest session after the first exploration of a novel environment are needed for the stabilization of the CA1 code, which process requires plasticity. We found that the newly-formed representation in the CA1 has the same level of stability with optogenetic SWR blockade as with a control manipulation that delivered the same amount of light into the brain. Therefore our results suggest that at least in the case of passive exploratory behavior, SWR-related plasticity is dispensable for the stability of CA1 ensembles. https://research-explorer.ista.ac.at/download/1279/5009/IST-2016-690-v1+1_journal.pone.0164675.PDF application/pdfno Public Library of Science2016 eng 00038620400004310.1371/journal.pone.0164675 1110 Kovács K, O’Neill J, Schönenberger P, Penttonen M, Rangel Guerrero DK, Csicsvari JL. Optogenetically blocking sharp wave ripple events in sleep does not interfere with the formation of stable spatial representation in the CA1 area of the hippocampus. <i>PLoS One</i>. 2016;11(10). doi:<a href="https://doi.org/10.1371/journal.pone.0164675">10.1371/journal.pone.0164675</a> Kovács, Krisztián, et al. “Optogenetically Blocking Sharp Wave Ripple Events in Sleep Does Not Interfere with the Formation of Stable Spatial Representation in the CA1 Area of the Hippocampus.” <i>PLoS One</i>, vol. 11, no. 10, e0164675, Public Library of Science, 2016, doi:<a href="https://doi.org/10.1371/journal.pone.0164675">10.1371/journal.pone.0164675</a>. K. Kovács, J. O’Neill, P. Schönenberger, M. Penttonen, D. K. Rangel Guerrero, and J. L. Csicsvari, “Optogenetically blocking sharp wave ripple events in sleep does not interfere with the formation of stable spatial representation in the CA1 area of the hippocampus,” <i>PLoS One</i>, vol. 11, no. 10. Public Library of Science, 2016. Kovács, K., O’Neill, J., Schönenberger, P., Penttonen, M., Rangel Guerrero, D. K., &#38; Csicsvari, J. L. (2016). Optogenetically blocking sharp wave ripple events in sleep does not interfere with the formation of stable spatial representation in the CA1 area of the hippocampus. <i>PLoS One</i>. Public Library of Science. <a href="https://doi.org/10.1371/journal.pone.0164675">https://doi.org/10.1371/journal.pone.0164675</a> Kovács, Krisztián, Joseph O’Neill, Philipp Schönenberger, Markku Penttonen, Dámaris K Rangel Guerrero, and Jozsef L Csicsvari. “Optogenetically Blocking Sharp Wave Ripple Events in Sleep Does Not Interfere with the Formation of Stable Spatial Representation in the CA1 Area of the Hippocampus.” <i>PLoS One</i>. Public Library of Science, 2016. <a href="https://doi.org/10.1371/journal.pone.0164675">https://doi.org/10.1371/journal.pone.0164675</a>. K. Kovács, J. O’Neill, P. Schönenberger, M. Penttonen, D.K. Rangel Guerrero, J.L. Csicsvari, PLoS One 11 (2016). Kovács K, O’Neill J, Schönenberger P, Penttonen M, Rangel Guerrero DK, Csicsvari JL. 2016. Optogenetically blocking sharp wave ripple events in sleep does not interfere with the formation of stable spatial representation in the CA1 area of the hippocampus. PLoS One. 11(10), e0164675. 12792018-12-11T11:51:06Z2025-09-22T08:36:27Z