---
res:
  bibo_abstract:
  - Despite the considerable progress of in vivo neural recording techniques, inferring
    the biophysical mechanisms underlying large scale coordination of brain activity
    from neural data remains challenging. One obstacle is the difficulty to link high
    dimensional functional connectivity measures to mechanistic models of network
    activity. We address this issue by investigating spike-field coupling (SFC) measurements,
    which quantify the synchronization between, on the one hand, the action potentials
    produced by neurons, and on the other hand mesoscopic “field” signals, reflecting
    subthreshold activities at possibly multiple recording sites. As the number of
    recording sites gets large, the amount of pairwise SFC measurements becomes overwhelmingly
    challenging to interpret. We develop Generalized Phase Locking Analysis (GPLA)
    as an interpretable dimensionality reduction of this multivariate SFC. GPLA describes
    the dominant coupling between field activity and neural ensembles across space
    and frequencies. We show that GPLA features are biophysically interpretable when
    used in conjunction with appropriate network models, such that we can identify
    the influence of underlying circuit properties on these features. We demonstrate
    the statistical benefits and interpretability of this approach in various computational
    models and Utah array recordings. The results suggest that GPLA, used jointly
    with biophysical modeling, can help uncover the contribution of recurrent microcircuits
    to the spatio-temporal dynamics observed in multi-channel experimental recordings.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Shervin
      foaf_name: Safavi, Shervin
      foaf_surname: Safavi
  - foaf_Person:
      foaf_givenName: Theofanis I.
      foaf_name: Panagiotaropoulos, Theofanis I.
      foaf_surname: Panagiotaropoulos
  - foaf_Person:
      foaf_givenName: Vishal
      foaf_name: Kapoor, Vishal
      foaf_surname: Kapoor
  - foaf_Person:
      foaf_givenName: Juan F
      foaf_name: Ramirez Villegas, Juan F
      foaf_surname: Ramirez Villegas
      foaf_workInfoHomepage: http://www.librecat.org/personId=44B06F76-F248-11E8-B48F-1D18A9856A87
  - foaf_Person:
      foaf_givenName: Nikos K.
      foaf_name: Logothetis, Nikos K.
      foaf_surname: Logothetis
  - foaf_Person:
      foaf_givenName: Michel
      foaf_name: Besserve, Michel
      foaf_surname: Besserve
  bibo_doi: 10.1371/journal.pcbi.1010983
  bibo_issue: '4'
  bibo_volume: 19
  dct_date: 2023^xs_gYear
  dct_identifier:
  - UT:000962668700002
  dct_isPartOf:
  - http://id.crossref.org/issn/1553-7358
  dct_language: eng
  dct_publisher: Public Library of Science@
  dct_title: Uncovering the organization of neural circuits with Generalized Phase
    Locking Analysis@
  fabio_hasPubmedId: '37011110'
...