--- res: bibo_abstract: - We developed a competition-based screening strategy to identify compounds that invert the selective advantage of antibiotic resistance. Using our assay, we screened over 19,000 compounds for the ability to select against the TetA tetracycline-resistance efflux pump in Escherichia coli and identified two hits, β-thujaplicin and disulfiram. Treating a tetracycline-resistant population with β-thujaplicin selects for loss of the resistance gene, enabling an effective second-phase treatment with doxycycline.@eng bibo_authorlist: - foaf_Person: foaf_givenName: Laura foaf_name: Stone, Laura foaf_surname: Stone - foaf_Person: foaf_givenName: Michael foaf_name: Baym, Michael foaf_surname: Baym - foaf_Person: foaf_givenName: Tami foaf_name: Lieberman, Tami foaf_surname: Lieberman - foaf_Person: foaf_givenName: Remy P foaf_name: Chait, Remy P foaf_surname: Chait foaf_workInfoHomepage: http://www.librecat.org/personId=3464AE84-F248-11E8-B48F-1D18A9856A87 orcid: 0000-0003-0876-3187 - foaf_Person: foaf_givenName: Jon foaf_name: Clardy, Jon foaf_surname: Clardy - foaf_Person: foaf_givenName: Roy foaf_name: Kishony, Roy foaf_surname: Kishony bibo_doi: 10.1038/nchembio.2176 bibo_issue: '11' bibo_volume: 12 dct_date: 2016^xs_gYear dct_language: eng dct_publisher: Nature Publishing Group@ dct_title: Compounds that select against the tetracycline-resistance efflux pump@ ...