--- _id: '1304' abstract: - lang: eng text: When confronted with a large-field stimulus rotating around the vertical body axis, flies display a following behavior called "optomotor response." As neural control elements, the large tangential horizontal system (HS) cells of the lobula plate have been prime candidates for long. Here, we applied optogenetic stimulation of HS cells to evaluate their behavioral role in Drosophila. To minimize interference of the optical activation of channelrhodopsin-2 with the visual perception of the flies, we used a bistable variant called ChR2-C128S. By applying pulses of blue and yellow light, we first demonstrate electrophysiologically that lobula plate tangential cells can be activated and deactivated repeatedly with no evident change in depolarization strength over trials. We next show that selective optogenetic activation of HS cells elicits robust yaw head movements and yaw turning responses in fixed and tethered flying flies, respectively. acknowledgement: 'This work was supported by the Max Planck Society. ' author: - first_name: Väinö full_name: Haikala, Väinö last_name: Haikala - first_name: Maximilian A full_name: Maximilian Jösch id: 2BD278E6-F248-11E8-B48F-1D18A9856A87 last_name: Jösch orcid: 0000-0002-3937-1330 - first_name: Alexander full_name: Borst, Alexander last_name: Borst - first_name: Alex full_name: Mauss, Alex S last_name: Mauss citation: ama: Haikala V, Jösch MA, Borst A, Mauss A. Optogenetic control of fly optomotor responses. Journal of Neuroscience. 2013;33(34):13927-13934. doi:10.1523/JNEUROSCI.0340-13.2013 apa: Haikala, V., Jösch, M. A., Borst, A., & Mauss, A. (2013). Optogenetic control of fly optomotor responses. Journal of Neuroscience. Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.0340-13.2013 chicago: Haikala, Väinö, Maximilian A Jösch, Alexander Borst, and Alex Mauss. “Optogenetic Control of Fly Optomotor Responses.” Journal of Neuroscience. Society for Neuroscience, 2013. https://doi.org/10.1523/JNEUROSCI.0340-13.2013. ieee: V. Haikala, M. A. Jösch, A. Borst, and A. Mauss, “Optogenetic control of fly optomotor responses,” Journal of Neuroscience, vol. 33, no. 34. Society for Neuroscience, pp. 13927–13934, 2013. ista: Haikala V, Jösch MA, Borst A, Mauss A. 2013. Optogenetic control of fly optomotor responses. Journal of Neuroscience. 33(34), 13927–13934. mla: Haikala, Väinö, et al. “Optogenetic Control of Fly Optomotor Responses.” Journal of Neuroscience, vol. 33, no. 34, Society for Neuroscience, 2013, pp. 13927–34, doi:10.1523/JNEUROSCI.0340-13.2013. short: V. Haikala, M.A. Jösch, A. Borst, A. Mauss, Journal of Neuroscience 33 (2013) 13927–13934. date_created: 2018-12-11T11:51:16Z date_published: 2013-01-01T00:00:00Z date_updated: 2021-01-12T06:49:45Z day: '01' doi: 10.1523/JNEUROSCI.0340-13.2013 extern: 1 intvolume: ' 33' issue: '34' month: '01' page: 13927 - 13934 publication: Journal of Neuroscience publication_status: published publisher: Society for Neuroscience publist_id: '5967' quality_controlled: 0 status: public title: Optogenetic control of fly optomotor responses type: journal_article volume: 33 year: '2013' ...