{"year":"2021","status":"public","date_published":"2021-12-25T00:00:00Z","day":"25","date_updated":"2023-08-14T11:53:26Z","related_material":{"record":[{"id":"10322","relation":"used_in_publication","status":"public"}]},"department":[{"_id":"MaDe"}],"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","image":"/images/cc_by.png"},"_id":"13069","type":"research_data_reference","doi":"10.5281/ZENODO.5519410","oa_version":"Published Version","abstract":[{"lang":"eng","text":"To survive elevated temperatures, ectotherms adjust the fluidity of membranes by fine-tuning lipid desaturation levels in a process previously described to be cell-autonomous. We have discovered that, in Caenorhabditis elegans, neuronal Heat shock Factor 1 (HSF-1), the conserved master regulator of the heat shock response (HSR)- causes extensive fat remodelling in peripheral tissues. These changes include a decrease in fat desaturase and acid lipase expression in the intestine, and a global shift in the saturation levels of plasma membrane’s phospholipids. The observed remodelling of plasma membrane is in line with ectothermic adaptive responses and gives worms a cumulative advantage to warm temperatures. We have determined that at least six TAX-2/TAX-4 cGMP gated channel expressing sensory neurons and TGF-β/BMP are required for signalling across tissues to modulate fat desaturation. We also find neuronal hsf-1  is not only sufficient but also partially necessary to control the fat remodelling response and for survival at warm temperatures. This is the first study to show that a thermostat-based mechanism can cell non-autonomously coordinate membrane saturation and composition across tissues in a multicellular animal."}],"author":[{"first_name":"Laetitia","full_name":"Chauve, Laetitia","last_name":"Chauve"},{"full_name":"Hodge, Francesca","last_name":"Hodge","first_name":"Francesca"},{"full_name":"Murdoch, Sharlene","last_name":"Murdoch","first_name":"Sharlene"},{"first_name":"Fatemah","last_name":"Masoudzadeh","full_name":"Masoudzadeh, Fatemah"},{"first_name":"Harry-Jack","full_name":"Mann, Harry-Jack","last_name":"Mann"},{"first_name":"Andrea","last_name":"Lopez-Clavijo","full_name":"Lopez-Clavijo, Andrea"},{"full_name":"Okkenhaug, Hanneke","last_name":"Okkenhaug","first_name":"Hanneke"},{"first_name":"Greg","full_name":"West, Greg","last_name":"West"},{"first_name":"Bebiana C.","full_name":"Sousa, Bebiana C.","last_name":"Sousa"},{"first_name":"Anne","last_name":"Segonds-Pichon","full_name":"Segonds-Pichon, Anne"},{"first_name":"Cheryl","full_name":"Li, Cheryl","last_name":"Li"},{"last_name":"Wingett","full_name":"Wingett, Steven","first_name":"Steven"},{"last_name":"Kienberger","full_name":"Kienberger, Hermine","first_name":"Hermine"},{"first_name":"Karin","last_name":"Kleigrewe","full_name":"Kleigrewe, Karin"},{"orcid":"0000-0001-8347-0443","first_name":"Mario","id":"4E3FF80E-F248-11E8-B48F-1D18A9856A87","last_name":"de Bono","full_name":"de Bono, Mario"},{"full_name":"Wakelam, Michael","last_name":"Wakelam","first_name":"Michael"},{"first_name":"Olivia","last_name":"Casanueva","full_name":"Casanueva, Olivia"}],"date_created":"2023-05-23T16:40:56Z","main_file_link":[{"url":"https://doi.org/10.5281/zenodo.5547464","open_access":"1"}],"citation":{"ieee":"L. Chauve <i>et al.</i>, “Neuronal HSF-1 coordinates the propagation of fat desaturation across tissues to enable adaptation to high temperatures in C. elegans.” Zenodo, 2021.","apa":"Chauve, L., Hodge, F., Murdoch, S., Masoudzadeh, F., Mann, H.-J., Lopez-Clavijo, A., … Casanueva, O. (2021). Neuronal HSF-1 coordinates the propagation of fat desaturation across tissues to enable adaptation to high temperatures in C. elegans. Zenodo. <a href=\"https://doi.org/10.5281/ZENODO.5519410\">https://doi.org/10.5281/ZENODO.5519410</a>","chicago":"Chauve, Laetitia, Francesca Hodge, Sharlene Murdoch, Fatemah Masoudzadeh, Harry-Jack Mann, Andrea Lopez-Clavijo, Hanneke Okkenhaug, et al. “Neuronal HSF-1 Coordinates the Propagation of Fat Desaturation across Tissues to Enable Adaptation to High Temperatures in C. Elegans.” Zenodo, 2021. <a href=\"https://doi.org/10.5281/ZENODO.5519410\">https://doi.org/10.5281/ZENODO.5519410</a>.","short":"L. Chauve, F. Hodge, S. Murdoch, F. Masoudzadeh, H.-J. Mann, A. Lopez-Clavijo, H. Okkenhaug, G. West, B.C. Sousa, A. Segonds-Pichon, C. Li, S. Wingett, H. Kienberger, K. Kleigrewe, M. de Bono, M. Wakelam, O. Casanueva, (2021).","ama":"Chauve L, Hodge F, Murdoch S, et al. Neuronal HSF-1 coordinates the propagation of fat desaturation across tissues to enable adaptation to high temperatures in C. elegans. 2021. doi:<a href=\"https://doi.org/10.5281/ZENODO.5519410\">10.5281/ZENODO.5519410</a>","mla":"Chauve, Laetitia, et al. <i>Neuronal HSF-1 Coordinates the Propagation of Fat Desaturation across Tissues to Enable Adaptation to High Temperatures in C. Elegans</i>. Zenodo, 2021, doi:<a href=\"https://doi.org/10.5281/ZENODO.5519410\">10.5281/ZENODO.5519410</a>.","ista":"Chauve L, Hodge F, Murdoch S, Masoudzadeh F, Mann H-J, Lopez-Clavijo A, Okkenhaug H, West G, Sousa BC, Segonds-Pichon A, Li C, Wingett S, Kienberger H, Kleigrewe K, de Bono M, Wakelam M, Casanueva O. 2021. Neuronal HSF-1 coordinates the propagation of fat desaturation across tissues to enable adaptation to high temperatures in C. elegans, Zenodo, <a href=\"https://doi.org/10.5281/ZENODO.5519410\">10.5281/ZENODO.5519410</a>."},"article_processing_charge":"No","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","month":"12","publisher":"Zenodo","oa":1,"ddc":["570"],"title":"Neuronal HSF-1 coordinates the propagation of fat desaturation across tissues to enable adaptation to high temperatures in C. elegans"}