---
res:
  bibo_abstract:
  - Disulfide bond formation is fundamentally important for protein structure and
    constitutes a key mechanism by which cells regulate the intracellular oxidation
    state. Peroxiredoxins (PRDXs) eliminate reactive oxygen species such as hydrogen
    peroxide through a catalytic cycle of Cys oxidation and reduction. Additionally,
    upon Cys oxidation PRDXs undergo extensive conformational rearrangements that
    may underlie their presently structurally poorly defined functions as molecular
    chaperones. Rearrangements include high molecular-weight oligomerization, the
    dynamics of which are, however, poorly understood, as is the impact of disulfide
    bond formation on these properties. Here we show that formation of disulfide bonds
    along the catalytic cycle induces extensive μs time scale dynamics, as monitored
    by magic-angle spinning NMR of the 216 kDa-large Tsa1 decameric assembly and solution-NMR
    of a designed dimeric mutant. We ascribe the conformational dynamics to structural
    frustration, resulting from conflicts between the disulfide-constrained reduction
    of mobility and the desire to fulfill other favorable contacts.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Laura
      foaf_name: Troussicot, Laura
      foaf_surname: Troussicot
      foaf_workInfoHomepage: http://www.librecat.org/personId=3d9cac31-413c-11eb-9514-d1ec2a7fb7f3
    orcid: 0000-0001-8297-8886
  - foaf_Person:
      foaf_givenName: Alicia
      foaf_name: Vallet, Alicia
      foaf_surname: Vallet
  - foaf_Person:
      foaf_givenName: Mikael
      foaf_name: Molin, Mikael
      foaf_surname: Molin
  - foaf_Person:
      foaf_givenName: Björn M.
      foaf_name: Burmann, Björn M.
      foaf_surname: Burmann
  - foaf_Person:
      foaf_givenName: Paul
      foaf_name: Schanda, Paul
      foaf_surname: Schanda
      foaf_workInfoHomepage: http://www.librecat.org/personId=7B541462-FAF6-11E9-A490-E8DFE5697425
    orcid: 0000-0002-9350-7606
  bibo_doi: 10.1021/jacs.3c01200
  bibo_issue: '19'
  bibo_volume: 145
  dct_date: 2023^xs_gYear
  dct_identifier:
  - UT:000985907400001
  dct_isPartOf:
  - http://id.crossref.org/issn/0002-7863
  - http://id.crossref.org/issn/1520-5126
  dct_language: eng
  dct_publisher: American Chemical Society@
  dct_title: Disulfide-bond-induced structural frustration and dynamic disorder in
    a peroxiredoxin from MAS NMR@
  fabio_hasPubmedId: '37140345'
...