--- res: bibo_abstract: - XY systems usually show chromosome-wide compensation of X-linked genes, while in many ZW systems, compensation is restricted to a minority of dosage-sensitive genes. Why such differences arose is still unclear. Here, we combine comparative genomics, transcriptomics and proteomics to obtain a complete overview of the evolution of gene dosage on the Z-chromosome of Schistosoma parasites. We compare the Z-chromosome gene content of African (Schistosoma mansoni and S. haematobium) and Asian (S. japonicum) schistosomes and describe lineage-specific evolutionary strata. We use these to assess gene expression evolution following sex-linkage. The resulting patterns suggest a reduction in expression of Z-linked genes in females, combined with upregulation of the Z in both sexes, in line with the first step of Ohno’s classic model of dosage compensation evolution. Quantitative proteomics suggest that post-transcriptional mechanisms do not play a major role in balancing the expression of Z-linked genes. @eng bibo_authorlist: - foaf_Person: foaf_givenName: Marion A foaf_name: Picard, Marion A foaf_surname: Picard foaf_workInfoHomepage: http://www.librecat.org/personId=2C921A7A-F248-11E8-B48F-1D18A9856A87 orcid: 0000-0002-8101-2518 - foaf_Person: foaf_givenName: Celine foaf_name: Cosseau, Celine foaf_surname: Cosseau - foaf_Person: foaf_givenName: Sabrina foaf_name: Ferré, Sabrina foaf_surname: Ferré - foaf_Person: foaf_givenName: Thomas foaf_name: Quack, Thomas foaf_surname: Quack - foaf_Person: foaf_givenName: Christoph foaf_name: Grevelding, Christoph foaf_surname: Grevelding - foaf_Person: foaf_givenName: Yohann foaf_name: Couté, Yohann foaf_surname: Couté - foaf_Person: foaf_givenName: Beatriz foaf_name: Vicoso, Beatriz foaf_surname: Vicoso foaf_workInfoHomepage: http://www.librecat.org/personId=49E1C5C6-F248-11E8-B48F-1D18A9856A87 orcid: 0000-0002-4579-8306 bibo_doi: 10.7554/eLife.35684 bibo_volume: 7 dct_date: 2018^xs_gYear dct_identifier: - UT:000441388200001 dct_language: eng dct_publisher: eLife Sciences Publications@ dct_title: Evolution of gene dosage on the Z-chromosome of schistosome parasites@ ...