---
_id: '131'
abstract:
- lang: eng
  text: 'XY systems usually show chromosome-wide compensation of X-linked genes, while
    in many ZW systems, compensation is restricted to a minority of dosage-sensitive
    genes. Why such differences arose is still unclear. Here, we combine comparative
    genomics, transcriptomics and proteomics to obtain a complete overview of the
    evolution of gene dosage on the Z-chromosome of Schistosoma parasites. We compare
    the Z-chromosome gene content of African (Schistosoma mansoni and S. haematobium)
    and Asian (S. japonicum) schistosomes and describe lineage-specific evolutionary
    strata. We use these to assess gene expression evolution following sex-linkage.
    The resulting patterns suggest a reduction in expression of Z-linked genes in
    females, combined with upregulation of the Z in both sexes, in line with the first
    step of Ohno’s classic model of dosage compensation evolution. Quantitative proteomics
    suggest that post-transcriptional mechanisms do not play a major role in balancing
    the expression of Z-linked genes. '
acknowledgement: We are grateful to Lu Dabing (Soochow University, Suzhou, China)
  for providing Schistosoma japonicum samples, to Ariana Macon (IST Austria) and Georgette
  Stovall (JLU Giessen) for technical assistance, to IT support at IST Austria for
  providing optimal environment to bioinformatic analyses, and to the Vicoso lab for
  comments on the manuscript.
article_number: e35684
article_processing_charge: No
article_type: original
author:
- first_name: Marion A
  full_name: Picard, Marion A
  id: 2C921A7A-F248-11E8-B48F-1D18A9856A87
  last_name: Picard
  orcid: 0000-0002-8101-2518
- first_name: Celine
  full_name: Cosseau, Celine
  last_name: Cosseau
- first_name: Sabrina
  full_name: Ferré, Sabrina
  last_name: Ferré
- first_name: Thomas
  full_name: Quack, Thomas
  last_name: Quack
- first_name: Christoph
  full_name: Grevelding, Christoph
  last_name: Grevelding
- first_name: Yohann
  full_name: Couté, Yohann
  last_name: Couté
- first_name: Beatriz
  full_name: Vicoso, Beatriz
  id: 49E1C5C6-F248-11E8-B48F-1D18A9856A87
  last_name: Vicoso
  orcid: 0000-0002-4579-8306
citation:
  ama: Picard MAL, Cosseau C, Ferré S, et al. Evolution of gene dosage on the Z-chromosome
    of schistosome parasites. <i>eLife</i>. 2018;7. doi:<a href="https://doi.org/10.7554/eLife.35684">10.7554/eLife.35684</a>
  apa: Picard, M. A. L., Cosseau, C., Ferré, S., Quack, T., Grevelding, C., Couté,
    Y., &#38; Vicoso, B. (2018). Evolution of gene dosage on the Z-chromosome of schistosome
    parasites. <i>ELife</i>. eLife Sciences Publications. <a href="https://doi.org/10.7554/eLife.35684">https://doi.org/10.7554/eLife.35684</a>
  chicago: Picard, Marion A L, Celine Cosseau, Sabrina Ferré, Thomas Quack, Christoph
    Grevelding, Yohann Couté, and Beatriz Vicoso. “Evolution of Gene Dosage on the
    Z-Chromosome of Schistosome Parasites.” <i>ELife</i>. eLife Sciences Publications,
    2018. <a href="https://doi.org/10.7554/eLife.35684">https://doi.org/10.7554/eLife.35684</a>.
  ieee: M. A. L. Picard <i>et al.</i>, “Evolution of gene dosage on the Z-chromosome
    of schistosome parasites,” <i>eLife</i>, vol. 7. eLife Sciences Publications,
    2018.
  ista: Picard MAL, Cosseau C, Ferré S, Quack T, Grevelding C, Couté Y, Vicoso B.
    2018. Evolution of gene dosage on the Z-chromosome of schistosome parasites. eLife.
    7, e35684.
  mla: Picard, Marion A. L., et al. “Evolution of Gene Dosage on the Z-Chromosome
    of Schistosome Parasites.” <i>ELife</i>, vol. 7, e35684, eLife Sciences Publications,
    2018, doi:<a href="https://doi.org/10.7554/eLife.35684">10.7554/eLife.35684</a>.
  short: M.A.L. Picard, C. Cosseau, S. Ferré, T. Quack, C. Grevelding, Y. Couté, B.
    Vicoso, ELife 7 (2018).
date_created: 2018-12-11T11:44:47Z
date_published: 2018-08-13T00:00:00Z
date_updated: 2025-04-15T08:18:37Z
day: '13'
ddc:
- '570'
department:
- _id: BeVi
doi: 10.7554/eLife.35684
external_id:
  isi:
  - '000441388200001'
file:
- access_level: open_access
  checksum: d6331d4385b1fffd6b47b45d5949d841
  content_type: application/pdf
  creator: dernst
  date_created: 2018-12-17T11:55:05Z
  date_updated: 2020-07-14T12:44:43Z
  file_id: '5695'
  file_name: 2018_eLife_Picard.pdf
  file_size: 3158125
  relation: main_file
file_date_updated: 2020-07-14T12:44:43Z
has_accepted_license: '1'
intvolume: '         7'
isi: 1
language:
- iso: eng
month: '08'
oa: 1
oa_version: Published Version
project:
- _id: 250ED89C-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: P28842-B22
  name: Sex chromosome evolution under male- and female- heterogamety
publication: eLife
publication_status: published
publisher: eLife Sciences Publications
publist_id: '7792'
quality_controlled: '1'
related_material:
  record:
  - id: '5586'
    relation: popular_science
    status: public
scopus_import: '1'
status: public
title: Evolution of gene dosage on the Z-chromosome of schistosome parasites
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 7
year: '2018'
...