--- res: bibo_abstract: - Urban-living individuals are exposed to many environmental factors that may combine and interact to influence mental health. While individual factors of an urban environment have been investigated in isolation, no attempt has been made to model how complex, real-life exposure to living in the city relates to brain and mental health, and how this is moderated by genetic factors. Using the data of 156,075 participants from the UK Biobank, we carried out sparse canonical correlation analyses to investigate the relationships between urban environments and psychiatric symptoms. We found an environmental profile of social deprivation, air pollution, street network and urban land-use density that was positively correlated with an affective symptom group (r = 0.22, Pperm < 0.001), mediated by brain volume differences consistent with reward processing, and moderated by genes enriched for stress response, including CRHR1, explaining 2.01% of the variance in brain volume differences. Protective factors such as greenness and generous destination accessibility were negatively correlated with an anxiety symptom group (r = 0.10, Pperm < 0.001), mediated by brain regions necessary for emotion regulation and moderated by EXD3, explaining 1.65% of the variance. The third urban environmental profile was correlated with an emotional instability symptom group (r = 0.03, Pperm < 0.001). Our findings suggest that different environmental profiles of urban living may influence specific psychiatric symptom groups through distinct neurobiological pathways.@eng bibo_authorlist: - foaf_Person: foaf_givenName: Jiayuan foaf_name: Xu, Jiayuan foaf_surname: Xu - foaf_Person: foaf_givenName: Nana foaf_name: Liu, Nana foaf_surname: Liu - foaf_Person: foaf_givenName: Elli foaf_name: Polemiti, Elli foaf_surname: Polemiti - foaf_Person: foaf_givenName: Liliana foaf_name: Garcia-Mondragon, Liliana foaf_surname: Garcia-Mondragon - foaf_Person: foaf_givenName: Jie foaf_name: Tang, Jie foaf_surname: Tang - foaf_Person: foaf_givenName: Xiaoxuan foaf_name: Liu, Xiaoxuan foaf_surname: Liu - foaf_Person: foaf_givenName: Tristram foaf_name: Lett, Tristram foaf_surname: Lett - foaf_Person: foaf_givenName: Le foaf_name: Yu, Le foaf_surname: Yu - foaf_Person: foaf_givenName: Markus M. foaf_name: Nöthen, Markus M. foaf_surname: Nöthen - foaf_Person: foaf_givenName: Jianfeng foaf_name: Feng, Jianfeng foaf_surname: Feng - foaf_Person: foaf_givenName: Chunshui foaf_name: Yu, Chunshui foaf_surname: Yu - foaf_Person: foaf_givenName: Andre foaf_name: Marquand, Andre foaf_surname: Marquand - foaf_Person: foaf_givenName: Gunter foaf_name: Schumann, Gunter foaf_surname: Schumann - foaf_Person: foaf_givenName: Henrik foaf_name: Walter, Henrik foaf_surname: Walter - foaf_Person: foaf_givenName: Andreas foaf_name: Heinz, Andreas foaf_surname: Heinz - foaf_Person: foaf_givenName: Markus foaf_name: Ralser, Markus foaf_surname: Ralser - foaf_Person: foaf_givenName: Sven foaf_name: Twardziok, Sven foaf_surname: Twardziok - foaf_Person: foaf_givenName: Nilakshi foaf_name: Vaidya, Nilakshi foaf_surname: Vaidya - foaf_Person: foaf_givenName: Emin foaf_name: Serin, Emin foaf_surname: Serin - foaf_Person: foaf_givenName: Marcel foaf_name: Jentsch, Marcel foaf_surname: Jentsch - foaf_Person: foaf_givenName: Esther foaf_name: Hitchen, Esther foaf_surname: Hitchen - foaf_Person: foaf_givenName: Roland foaf_name: Eils, Roland foaf_surname: Eils - foaf_Person: foaf_givenName: Ulrike Helene foaf_name: Taron, Ulrike Helene foaf_surname: Taron - foaf_Person: foaf_givenName: Tatjana foaf_name: Schütz, Tatjana foaf_surname: Schütz - foaf_Person: foaf_givenName: Kerstin foaf_name: Schepanski, Kerstin foaf_surname: Schepanski - foaf_Person: foaf_givenName: Jamie foaf_name: Banks, Jamie foaf_surname: Banks - foaf_Person: foaf_givenName: Tobias foaf_name: Banaschewski, Tobias foaf_surname: Banaschewski - foaf_Person: foaf_givenName: Karina foaf_name: Jansone, Karina foaf_surname: Jansone - foaf_Person: foaf_givenName: Nina foaf_name: Christmann, Nina foaf_surname: Christmann - foaf_Person: foaf_givenName: Andreas foaf_name: Meyer-Lindenberg, Andreas foaf_surname: Meyer-Lindenberg - foaf_Person: foaf_givenName: Heike foaf_name: Tost, Heike foaf_surname: Tost - foaf_Person: foaf_givenName: Nathalie foaf_name: Holz, Nathalie foaf_surname: Holz - foaf_Person: foaf_givenName: Emanuel foaf_name: Schwarz, Emanuel foaf_surname: Schwarz - foaf_Person: foaf_givenName: Argyris foaf_name: Stringaris, Argyris foaf_surname: Stringaris - foaf_Person: foaf_givenName: Maja foaf_name: Neidhart, Maja foaf_surname: Neidhart - foaf_Person: foaf_givenName: Frauke foaf_name: Nees, Frauke foaf_surname: Nees - foaf_Person: foaf_givenName: Sebastian foaf_name: Siehl, Sebastian foaf_surname: Siehl - foaf_Person: foaf_givenName: Ole foaf_name: A. Andreassen, Ole foaf_surname: A. Andreassen - foaf_Person: foaf_givenName: Lars foaf_name: T. Westlye, Lars foaf_surname: T. Westlye - foaf_Person: foaf_givenName: Dennis foaf_name: Van Der Meer, Dennis foaf_surname: Van Der Meer - foaf_Person: foaf_givenName: Sara foaf_name: Fernandez, Sara foaf_surname: Fernandez - foaf_Person: foaf_givenName: Rikka foaf_name: Kjelkenes, Rikka foaf_surname: Kjelkenes - foaf_Person: foaf_givenName: Helga foaf_name: Ask, Helga foaf_surname: Ask - foaf_Person: foaf_givenName: Michael foaf_name: Rapp, Michael foaf_surname: Rapp - foaf_Person: foaf_givenName: Mira foaf_name: Tschorn, Mira foaf_surname: Tschorn - foaf_Person: foaf_givenName: Sarah Jane foaf_name: Böttger, Sarah Jane foaf_surname: Böttger - foaf_Person: foaf_givenName: Gaia foaf_name: Novarino, Gaia foaf_surname: Novarino foaf_workInfoHomepage: http://www.librecat.org/personId=3E57A680-F248-11E8-B48F-1D18A9856A87 orcid: 0000-0002-7673-7178 - foaf_Person: foaf_givenName: Lena foaf_name: Marr, Lena foaf_surname: Marr foaf_workInfoHomepage: http://www.librecat.org/personId=4406F586-F248-11E8-B48F-1D18A9856A87 - foaf_Person: foaf_givenName: Mel foaf_name: Slater, Mel foaf_surname: Slater - foaf_Person: foaf_givenName: Guillem Feixas foaf_name: Viapiana, Guillem Feixas foaf_surname: Viapiana - foaf_Person: foaf_givenName: Francisco Eiroa foaf_name: Orosa, Francisco Eiroa foaf_surname: Orosa - foaf_Person: foaf_givenName: Jaime foaf_name: Gallego, Jaime foaf_surname: Gallego - foaf_Person: foaf_givenName: Alvaro foaf_name: Pastor, Alvaro foaf_surname: Pastor - foaf_Person: foaf_givenName: Andreas foaf_name: Forstner, Andreas foaf_surname: Forstner - foaf_Person: foaf_givenName: Per foaf_name: Hoffmann, Per foaf_surname: Hoffmann - foaf_Person: foaf_givenName: Markus foaf_name: M. 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Young, Allan foaf_surname: H. Young - foaf_Person: foaf_givenName: Bernd foaf_name: Stahl, Bernd foaf_surname: Stahl - foaf_Person: foaf_givenName: George foaf_name: Ogoh, George foaf_surname: Ogoh bibo_doi: 10.1038/s41591-023-02365-w bibo_volume: 29 dct_date: 2023^xs_gYear dct_identifier: - UT:001013172700001 dct_isPartOf: - http://id.crossref.org/issn/1078-8956 - http://id.crossref.org/issn/1546-170X dct_language: eng dct_publisher: Springer Nature@ dct_title: Effects of urban living environments on mental health in adults@ ...