---
_id: '132'
abstract:
- lang: eng
text: Pancreas development involves a coordinated process in which an early phase
of cell segregation is followed by a longer phase of lineage restriction, expansion,
and tissue remodeling. By combining clonal tracing and whole-mount reconstruction
with proliferation kinetics and single-cell transcriptional profiling, we define
the functional basis of pancreas morphogenesis. We show that the large-scale organization
of mouse pancreas can be traced to the activity of self-renewing precursors positioned
at the termini of growing ducts, which act collectively to drive serial rounds
of stochastic ductal bifurcation balanced by termination. During this phase of
branching morphogenesis, multipotent precursors become progressively fate-restricted,
giving rise to self-renewing acinar-committed precursors that are conveyed with
growing ducts, as well as ductal progenitors that expand the trailing ducts and
give rise to delaminating endocrine cells. These findings define quantitatively
how the functional behavior and lineage progression of precursor pools determine
the large-scale patterning of pancreatic sub-compartments.
acknowledgement: E.H. is funded by a Junior Research Fellowship from Trinity College,
Cam-bridge, a Sir Henry Wellcome Fellowship from the Wellcome Trust, and theBettencourt-Schueller
Young Researcher Prize for support.
article_processing_charge: No
article_type: original
author:
- first_name: Magdalena
full_name: Sznurkowska, Magdalena
last_name: Sznurkowska
- first_name: Edouard B
full_name: Hannezo, Edouard B
id: 3A9DB764-F248-11E8-B48F-1D18A9856A87
last_name: Hannezo
orcid: 0000-0001-6005-1561
- first_name: Roberta
full_name: Azzarelli, Roberta
last_name: Azzarelli
- first_name: Steffen
full_name: Rulands, Steffen
last_name: Rulands
- first_name: Sonia
full_name: Nestorowa, Sonia
last_name: Nestorowa
- first_name: Christopher
full_name: Hindley, Christopher
last_name: Hindley
- first_name: Jennifer
full_name: Nichols, Jennifer
last_name: Nichols
- first_name: Berthold
full_name: Göttgens, Berthold
last_name: Göttgens
- first_name: Meritxell
full_name: Huch, Meritxell
last_name: Huch
- first_name: Anna
full_name: Philpott, Anna
last_name: Philpott
- first_name: Benjamin
full_name: Simons, Benjamin
last_name: Simons
citation:
ama: Sznurkowska M, Hannezo EB, Azzarelli R, et al. Defining lineage potential and
fate behavior of precursors during pancreas development. Developmental Cell.
2018;46(3):360-375. doi:10.1016/j.devcel.2018.06.028
apa: Sznurkowska, M., Hannezo, E. B., Azzarelli, R., Rulands, S., Nestorowa, S.,
Hindley, C., … Simons, B. (2018). Defining lineage potential and fate behavior
of precursors during pancreas development. Developmental Cell. Cell Press.
https://doi.org/10.1016/j.devcel.2018.06.028
chicago: Sznurkowska, Magdalena, Edouard B Hannezo, Roberta Azzarelli, Steffen Rulands,
Sonia Nestorowa, Christopher Hindley, Jennifer Nichols, et al. “Defining Lineage
Potential and Fate Behavior of Precursors during Pancreas Development.” Developmental
Cell. Cell Press, 2018. https://doi.org/10.1016/j.devcel.2018.06.028.
ieee: M. Sznurkowska et al., “Defining lineage potential and fate behavior
of precursors during pancreas development,” Developmental Cell, vol. 46,
no. 3. Cell Press, pp. 360–375, 2018.
ista: Sznurkowska M, Hannezo EB, Azzarelli R, Rulands S, Nestorowa S, Hindley C,
Nichols J, Göttgens B, Huch M, Philpott A, Simons B. 2018. Defining lineage potential
and fate behavior of precursors during pancreas development. Developmental Cell.
46(3), 360–375.
mla: Sznurkowska, Magdalena, et al. “Defining Lineage Potential and Fate Behavior
of Precursors during Pancreas Development.” Developmental Cell, vol. 46,
no. 3, Cell Press, 2018, pp. 360–75, doi:10.1016/j.devcel.2018.06.028.
short: M. Sznurkowska, E.B. Hannezo, R. Azzarelli, S. Rulands, S. Nestorowa, C.
Hindley, J. Nichols, B. Göttgens, M. Huch, A. Philpott, B. Simons, Developmental
Cell 46 (2018) 360–375.
date_created: 2018-12-11T11:44:48Z
date_published: 2018-08-06T00:00:00Z
date_updated: 2023-09-11T12:52:41Z
day: '06'
ddc:
- '570'
department:
- _id: EdHa
doi: 10.1016/j.devcel.2018.06.028
external_id:
isi:
- '000441327300012'
file:
- access_level: open_access
checksum: 78d2062b9e3c3b90fe71545aeb6d2f65
content_type: application/pdf
creator: dernst
date_created: 2018-12-17T10:49:49Z
date_updated: 2020-07-14T12:44:43Z
file_id: '5694'
file_name: 2018_DevelopmentalCell_Sznurkowska.pdf
file_size: 8948384
relation: main_file
file_date_updated: 2020-07-14T12:44:43Z
has_accepted_license: '1'
intvolume: ' 46'
isi: 1
issue: '3'
language:
- iso: eng
month: '08'
oa: 1
oa_version: Published Version
page: 360 - 375
publication: Developmental Cell
publication_status: published
publisher: Cell Press
publist_id: '7791'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Defining lineage potential and fate behavior of precursors during pancreas
development
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 46
year: '2018'
...