--- _id: '132' abstract: - lang: eng text: Pancreas development involves a coordinated process in which an early phase of cell segregation is followed by a longer phase of lineage restriction, expansion, and tissue remodeling. By combining clonal tracing and whole-mount reconstruction with proliferation kinetics and single-cell transcriptional profiling, we define the functional basis of pancreas morphogenesis. We show that the large-scale organization of mouse pancreas can be traced to the activity of self-renewing precursors positioned at the termini of growing ducts, which act collectively to drive serial rounds of stochastic ductal bifurcation balanced by termination. During this phase of branching morphogenesis, multipotent precursors become progressively fate-restricted, giving rise to self-renewing acinar-committed precursors that are conveyed with growing ducts, as well as ductal progenitors that expand the trailing ducts and give rise to delaminating endocrine cells. These findings define quantitatively how the functional behavior and lineage progression of precursor pools determine the large-scale patterning of pancreatic sub-compartments. acknowledgement: E.H. is funded by a Junior Research Fellowship from Trinity College, Cam-bridge, a Sir Henry Wellcome Fellowship from the Wellcome Trust, and theBettencourt-Schueller Young Researcher Prize for support. article_processing_charge: No article_type: original author: - first_name: Magdalena full_name: Sznurkowska, Magdalena last_name: Sznurkowska - first_name: Edouard B full_name: Hannezo, Edouard B id: 3A9DB764-F248-11E8-B48F-1D18A9856A87 last_name: Hannezo orcid: 0000-0001-6005-1561 - first_name: Roberta full_name: Azzarelli, Roberta last_name: Azzarelli - first_name: Steffen full_name: Rulands, Steffen last_name: Rulands - first_name: Sonia full_name: Nestorowa, Sonia last_name: Nestorowa - first_name: Christopher full_name: Hindley, Christopher last_name: Hindley - first_name: Jennifer full_name: Nichols, Jennifer last_name: Nichols - first_name: Berthold full_name: Göttgens, Berthold last_name: Göttgens - first_name: Meritxell full_name: Huch, Meritxell last_name: Huch - first_name: Anna full_name: Philpott, Anna last_name: Philpott - first_name: Benjamin full_name: Simons, Benjamin last_name: Simons citation: ama: Sznurkowska M, Hannezo EB, Azzarelli R, et al. Defining lineage potential and fate behavior of precursors during pancreas development. Developmental Cell. 2018;46(3):360-375. doi:10.1016/j.devcel.2018.06.028 apa: Sznurkowska, M., Hannezo, E. B., Azzarelli, R., Rulands, S., Nestorowa, S., Hindley, C., … Simons, B. (2018). Defining lineage potential and fate behavior of precursors during pancreas development. Developmental Cell. Cell Press. https://doi.org/10.1016/j.devcel.2018.06.028 chicago: Sznurkowska, Magdalena, Edouard B Hannezo, Roberta Azzarelli, Steffen Rulands, Sonia Nestorowa, Christopher Hindley, Jennifer Nichols, et al. “Defining Lineage Potential and Fate Behavior of Precursors during Pancreas Development.” Developmental Cell. Cell Press, 2018. https://doi.org/10.1016/j.devcel.2018.06.028. ieee: M. Sznurkowska et al., “Defining lineage potential and fate behavior of precursors during pancreas development,” Developmental Cell, vol. 46, no. 3. Cell Press, pp. 360–375, 2018. ista: Sznurkowska M, Hannezo EB, Azzarelli R, Rulands S, Nestorowa S, Hindley C, Nichols J, Göttgens B, Huch M, Philpott A, Simons B. 2018. Defining lineage potential and fate behavior of precursors during pancreas development. Developmental Cell. 46(3), 360–375. mla: Sznurkowska, Magdalena, et al. “Defining Lineage Potential and Fate Behavior of Precursors during Pancreas Development.” Developmental Cell, vol. 46, no. 3, Cell Press, 2018, pp. 360–75, doi:10.1016/j.devcel.2018.06.028. short: M. Sznurkowska, E.B. Hannezo, R. Azzarelli, S. Rulands, S. Nestorowa, C. Hindley, J. Nichols, B. Göttgens, M. Huch, A. Philpott, B. Simons, Developmental Cell 46 (2018) 360–375. date_created: 2018-12-11T11:44:48Z date_published: 2018-08-06T00:00:00Z date_updated: 2023-09-11T12:52:41Z day: '06' ddc: - '570' department: - _id: EdHa doi: 10.1016/j.devcel.2018.06.028 external_id: isi: - '000441327300012' file: - access_level: open_access checksum: 78d2062b9e3c3b90fe71545aeb6d2f65 content_type: application/pdf creator: dernst date_created: 2018-12-17T10:49:49Z date_updated: 2020-07-14T12:44:43Z file_id: '5694' file_name: 2018_DevelopmentalCell_Sznurkowska.pdf file_size: 8948384 relation: main_file file_date_updated: 2020-07-14T12:44:43Z has_accepted_license: '1' intvolume: ' 46' isi: 1 issue: '3' language: - iso: eng month: '08' oa: 1 oa_version: Published Version page: 360 - 375 publication: Developmental Cell publication_status: published publisher: Cell Press publist_id: '7791' quality_controlled: '1' scopus_import: '1' status: public title: Defining lineage potential and fate behavior of precursors during pancreas development tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1 volume: 46 year: '2018' ...