---
res:
  bibo_abstract:
  - The potential of immune-evasive mutation accumulation in the SARS-CoV-2 virus
    has led to its rapid spread, causing over 600 million confirmed cases and more
    than 6.5 million confirmed deaths. The huge demand for the rapid development and
    deployment of low-cost and effective vaccines against emerging variants has renewed
    interest in DNA vaccine technology. Here, we report the rapid generation and immunological
    evaluation of novel DNA vaccine candidates against the Wuhan-Hu-1 and Omicron
    variants based on the RBD protein fused with the Potato virus X coat protein (PVXCP).
    The delivery of DNA vaccines using electroporation in a two-dose regimen induced
    high-antibody titers and profound cellular responses in mice. The antibody titers
    induced against the Omicron variant of the vaccine were sufficient for effective
    protection against both Omicron and Wuhan-Hu-1 virus infections. The PVXCP protein
    in the vaccine construct shifted the immune response to the favorable Th1-like
    type and provided the oligomerization of RBD-PVXCP protein. Naked DNA delivery
    by needle-free injection allowed us to achieve antibody titers comparable with
    mRNA-LNP delivery in rabbits. These data identify the RBD-PVXCP DNA vaccine platform
    as a promising solution for robust and effective SARS-CoV-2 protection, supporting
    further translational study.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Dmitri
      foaf_name: Dormeshkin, Dmitri
      foaf_surname: Dormeshkin
  - foaf_Person:
      foaf_givenName: Mikalai
      foaf_name: Katsin, Mikalai
      foaf_surname: Katsin
  - foaf_Person:
      foaf_givenName: Maria
      foaf_name: Stegantseva, Maria
      foaf_surname: Stegantseva
  - foaf_Person:
      foaf_givenName: Sergey
      foaf_name: Golenchenko, Sergey
      foaf_surname: Golenchenko
  - foaf_Person:
      foaf_givenName: Michail
      foaf_name: Shapira, Michail
      foaf_surname: Shapira
  - foaf_Person:
      foaf_givenName: Simon
      foaf_name: Dubovik, Simon
      foaf_surname: Dubovik
  - foaf_Person:
      foaf_givenName: Dzmitry
      foaf_name: Lutskovich, Dzmitry
      foaf_surname: Lutskovich
  - foaf_Person:
      foaf_givenName: Anton
      foaf_name: Kavaleuski, Anton
      foaf_surname: Kavaleuski
      foaf_workInfoHomepage: http://www.librecat.org/personId=62304f89-eb97-11eb-a6c2-8903dd183976
    orcid: 0000-0003-2091-526X
  - foaf_Person:
      foaf_givenName: Alexander
      foaf_name: Meleshko, Alexander
      foaf_surname: Meleshko
  bibo_doi: 10.3390/vaccines11061014
  bibo_issue: '6'
  bibo_volume: 11
  dct_date: 2023^xs_gYear
  dct_identifier:
  - UT:001017740000001
  dct_isPartOf:
  - http://id.crossref.org/issn/2076-393X
  dct_language: eng
  dct_publisher: MDPI@
  dct_title: Design and immunogenicity of SARS-CoV-2 DNA vaccine encoding RBD-PVXCP
    fusion protein@
  fabio_hasPubmedId: '37376403'
...