--- res: bibo_abstract: - Antibiotic-sensitive and -resistant bacteria coexist in natural environments with low, if detectable, antibiotic concentrations. Except possibly around localized antibiotic sources, where resistance can provide a strong advantage, bacterial fitness is dominated by stresses unaffected by resistance to the antibiotic. How do such mixed and heterogeneous conditions influence the selective advantage or disadvantage of antibiotic resistance? Here we find that sub-inhibitory levels of tetracyclines potentiate selection for or against tetracycline resistance around localized sources of almost any toxin or stress. Furthermore, certain stresses generate alternating rings of selection for and against resistance around a localized source of the antibiotic. In these conditions, localized antibiotic sources, even at high strengths, can actually produce a net selection against resistance to the antibiotic. Our results show that interactions between the effects of an antibiotic and other stresses in inhomogeneous environments can generate pervasive, complex patterns of selection both for and against antibiotic resistance.@eng bibo_authorlist: - foaf_Person: foaf_givenName: Remy P foaf_name: Chait, Remy P foaf_surname: Chait foaf_workInfoHomepage: http://www.librecat.org/personId=3464AE84-F248-11E8-B48F-1D18A9856A87 orcid: 0000-0003-0876-3187 - foaf_Person: foaf_givenName: Adam foaf_name: Palmer, Adam foaf_surname: Palmer - foaf_Person: foaf_givenName: Idan foaf_name: Yelin, Idan foaf_surname: Yelin - foaf_Person: foaf_givenName: Roy foaf_name: Kishony, Roy foaf_surname: Kishony bibo_doi: 10.1038/ncomms10333 bibo_volume: 7 dct_date: 2016^xs_gYear dct_language: eng dct_publisher: Nature Publishing Group@ dct_title: Pervasive selection for and against antibiotic resistance in inhomogeneous multistress environments@ ...