---
res:
  bibo_abstract:
  - 'Supramolecular self-assembly in biological systems holds promise to convert and
    amplify disease-specific signals to physical or mechanical signals that can direct
    cell fate. However, it remains challenging to design physiologically stable self-assembling
    systems that demonstrate tunable and predictable behavior. Here, the use of zwitterionic
    tetrapeptide modalities to direct nanoparticle assembly under physiological conditions
    is reported. The self-assembly of gold nanoparticles can be activated by enzymatic
    unveiling of surface-bound zwitterionic tetrapeptides through matrix metalloprotease-9
    (MMP-9), which is overexpressed by cancer cells. This robust nanoparticle assembly
    is achieved by multivalent, self-complementary interactions of the zwitterionic
    tetrapeptides. In cancer cells that overexpress MMP-9, the nanoparticle assembly
    process occurs near the cell membrane and causes size-induced selection of cellular
    uptake mechanism, resulting in diminished cell growth. The enzyme responsiveness,
    and therefore, indirectly, the uptake route of the system can be programmed by
    customizing the peptide sequence: a simple inversion of the two amino acids at
    the cleavage site completely inactivates the enzyme responsiveness, self-assembly,
    and consequently changes the endocytic pathway. This robust self-complementary,
    zwitterionic peptide design demonstrates the use of enzyme-activated electrostatic
    side-chain patterns as powerful and customizable peptide modalities to program
    nanoparticle self-assembly and alter cellular response in biological context.@eng'
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Richard H.
      foaf_name: Huang, Richard H.
      foaf_surname: Huang
  - foaf_Person:
      foaf_givenName: Nazia
      foaf_name: Nayeem, Nazia
      foaf_surname: Nayeem
  - foaf_Person:
      foaf_givenName: Ye
      foaf_name: He, Ye
      foaf_surname: He
  - foaf_Person:
      foaf_givenName: Jorge
      foaf_name: Morales, Jorge
      foaf_surname: Morales
  - foaf_Person:
      foaf_givenName: Duncan
      foaf_name: Graham, Duncan
      foaf_surname: Graham
  - foaf_Person:
      foaf_givenName: Rafal
      foaf_name: Klajn, Rafal
      foaf_surname: Klajn
      foaf_workInfoHomepage: http://www.librecat.org/personId=8e84690e-1e48-11ed-a02b-a1e6fb8bb53b
  - foaf_Person:
      foaf_givenName: Maria
      foaf_name: Contel, Maria
      foaf_surname: Contel
  - foaf_Person:
      foaf_givenName: Stephen
      foaf_name: O'Brien, Stephen
      foaf_surname: O'Brien
  - foaf_Person:
      foaf_givenName: Rein V.
      foaf_name: Ulijn, Rein V.
      foaf_surname: Ulijn
  bibo_doi: 10.1002/adma.202104962
  bibo_issue: '1'
  bibo_volume: 34
  dct_date: 2022^xs_gYear
  dct_isPartOf:
  - http://id.crossref.org/issn/0935-9648
  - http://id.crossref.org/issn/1521-4095
  dct_language: eng
  dct_publisher: Wiley@
  dct_subject:
  - Mechanical Engineering
  - Mechanics of Materials
  - General Materials Science
  dct_title: Self‐complementary zwitterionic peptides direct nanoparticle assembly
    and enable enzymatic selection of endocytic pathways@
  fabio_hasPubmedId: '34668253'
...