---
res:
  bibo_abstract:
  - A key aspect of bacterial survival is the ability to evolve while migrating across
    spatially varying environmental challenges. Laboratory experiments, however, often
    study evolution in well-mixed systems. Here, we introduce an experimental device,
    the microbial evolution and growth arena (MEGA)-plate, in which bacteria spread
    and evolved on a large antibiotic landscape (120 × 60 centimeters) that allowed
    visual observation of mutation and selection in a migrating bacterial front.While
    resistance increased consistently, multiple coexisting lineages diversified both
    phenotypically and genotypically. Analyzing mutants at and behind the propagating
    front,we found that evolution is not always led by the most resistant mutants;
    highly resistant mutants may be trapped behindmore sensitive lineages.TheMEGA-plate
    provides a versatile platformfor studying microbial adaption and directly visualizing
    evolutionary dynamics.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Michael
      foaf_name: Baym, Michael
      foaf_surname: Baym
  - foaf_Person:
      foaf_givenName: Tami
      foaf_name: Lieberman, Tami
      foaf_surname: Lieberman
  - foaf_Person:
      foaf_givenName: Eric
      foaf_name: Kelsic, Eric
      foaf_surname: Kelsic
  - foaf_Person:
      foaf_givenName: Remy P
      foaf_name: Chait, Remy P
      foaf_surname: Chait
      foaf_workInfoHomepage: http://www.librecat.org/personId=3464AE84-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0003-0876-3187
  - foaf_Person:
      foaf_givenName: Rotem
      foaf_name: Gross, Rotem
      foaf_surname: Gross
  - foaf_Person:
      foaf_givenName: Idan
      foaf_name: Yelin, Idan
      foaf_surname: Yelin
  - foaf_Person:
      foaf_givenName: Roy
      foaf_name: Kishony, Roy
      foaf_surname: Kishony
  bibo_doi: 10.1126/science.aag0822
  bibo_issue: '6304'
  bibo_volume: 353
  dct_date: 2016^xs_gYear
  dct_identifier:
  - UT:000382626800052
  dct_language: eng
  dct_publisher: American Association for the Advancement of Science@
  dct_title: Spatiotemporal microbial evolution on antibiotic landscapes@
...