---
res:
  bibo_abstract:
  - ATP production requires the establishment of an electrochemical proton gradient
    across the inner mitochondrial membrane. Mitochondrial uncouplers dissipate this
    proton gradient and disrupt numerous cellular processes, including vesicular trafficking,
    mainly through energy depletion. Here we show that Endosidin9 (ES9), a novel mitochondrial
    uncoupler, is a potent inhibitor of clathrin-mediated endocytosis (CME) in different
    systems and that ES9 induces inhibition of CME not because of its effect on cellular
    ATP, but rather due to its protonophore activity that leads to cytoplasm acidification.
    We show that the known tyrosine kinase inhibitor tyrphostinA23, which is routinely
    used to block CME, displays similar properties, thus questioning its use as a
    specific inhibitor of cargo recognition by the AP-2 adaptor complex via tyrosine
    motif-based endocytosis signals. Furthermore, we show that cytoplasm acidification
    dramatically affects the dynamics and recruitment of clathrin and associated adaptors,
    and leads to reduction of phosphatidylinositol 4,5-biphosphate from the plasma
    membrane.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Wim
      foaf_name: Dejonghe, Wim
      foaf_surname: Dejonghe
  - foaf_Person:
      foaf_givenName: Sabine
      foaf_name: Kuenen, Sabine
      foaf_surname: Kuenen
  - foaf_Person:
      foaf_givenName: Evelien
      foaf_name: Mylle, Evelien
      foaf_surname: Mylle
  - foaf_Person:
      foaf_givenName: Mina K
      foaf_name: Vasileva, Mina K
      foaf_surname: Vasileva
      foaf_workInfoHomepage: http://www.librecat.org/personId=3407EB18-F248-11E8-B48F-1D18A9856A87
  - foaf_Person:
      foaf_givenName: Olivier
      foaf_name: Keech, Olivier
      foaf_surname: Keech
  - foaf_Person:
      foaf_givenName: Corrado
      foaf_name: Viotti, Corrado
      foaf_surname: Viotti
  - foaf_Person:
      foaf_givenName: Jef
      foaf_name: Swerts, Jef
      foaf_surname: Swerts
  - foaf_Person:
      foaf_givenName: Matyas
      foaf_name: Fendrych, Matyas
      foaf_surname: Fendrych
      foaf_workInfoHomepage: http://www.librecat.org/personId=43905548-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0002-9767-8699
  - foaf_Person:
      foaf_givenName: Fausto
      foaf_name: Ortiz Morea, Fausto
      foaf_surname: Ortiz Morea
  - foaf_Person:
      foaf_givenName: Kiril
      foaf_name: Mishev, Kiril
      foaf_surname: Mishev
  - foaf_Person:
      foaf_givenName: Simon
      foaf_name: Delang, Simon
      foaf_surname: Delang
  - foaf_Person:
      foaf_givenName: Stefan
      foaf_name: Scholl, Stefan
      foaf_surname: Scholl
  - foaf_Person:
      foaf_givenName: Xavier
      foaf_name: Zarza, Xavier
      foaf_surname: Zarza
  - foaf_Person:
      foaf_givenName: Mareike
      foaf_name: Heilmann, Mareike
      foaf_surname: Heilmann
  - foaf_Person:
      foaf_givenName: Jiorgos
      foaf_name: Kourelis, Jiorgos
      foaf_surname: Kourelis
  - foaf_Person:
      foaf_givenName: Jaroslaw
      foaf_name: Kasprowicz, Jaroslaw
      foaf_surname: Kasprowicz
  - foaf_Person:
      foaf_givenName: Le
      foaf_name: Nguyen, Le
      foaf_surname: Nguyen
  - foaf_Person:
      foaf_givenName: Andrzej
      foaf_name: Drozdzecki, Andrzej
      foaf_surname: Drozdzecki
  - foaf_Person:
      foaf_givenName: Isabelle
      foaf_name: Van Houtte, Isabelle
      foaf_surname: Van Houtte
  - foaf_Person:
      foaf_givenName: Anna
      foaf_name: Szatmári, Anna
      foaf_surname: Szatmári
  - foaf_Person:
      foaf_givenName: Mateusz
      foaf_name: Majda, Mateusz
      foaf_surname: Majda
  - foaf_Person:
      foaf_givenName: Gary
      foaf_name: Baisa, Gary
      foaf_surname: Baisa
  - foaf_Person:
      foaf_givenName: Sebastian
      foaf_name: Bednarek, Sebastian
      foaf_surname: Bednarek
  - foaf_Person:
      foaf_givenName: Stéphanie
      foaf_name: Robert, Stéphanie
      foaf_surname: Robert
  - foaf_Person:
      foaf_givenName: Dominique
      foaf_name: Audenaert, Dominique
      foaf_surname: Audenaert
  - foaf_Person:
      foaf_givenName: Christa
      foaf_name: Testerink, Christa
      foaf_surname: Testerink
  - foaf_Person:
      foaf_givenName: Teun
      foaf_name: Munnik, Teun
      foaf_surname: Munnik
  - foaf_Person:
      foaf_givenName: Daniël
      foaf_name: Van Damme, Daniël
      foaf_surname: Van Damme
  - foaf_Person:
      foaf_givenName: Ingo
      foaf_name: Heilmann, Ingo
      foaf_surname: Heilmann
  - foaf_Person:
      foaf_givenName: Karin
      foaf_name: Schumacher, Karin
      foaf_surname: Schumacher
  - foaf_Person:
      foaf_givenName: Johan
      foaf_name: Winne, Johan
      foaf_surname: Winne
  - foaf_Person:
      foaf_givenName: Jirí
      foaf_name: Friml, Jirí
      foaf_surname: Friml
      foaf_workInfoHomepage: http://www.librecat.org/personId=4159519E-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0002-8302-7596
  - foaf_Person:
      foaf_givenName: Patrik
      foaf_name: Verstreken, Patrik
      foaf_surname: Verstreken
  - foaf_Person:
      foaf_givenName: Eugenia
      foaf_name: Russinova, Eugenia
      foaf_surname: Russinova
  bibo_doi: 10.1038/ncomms11710
  bibo_volume: 7
  dct_date: 2016^xs_gYear
  dct_identifier:
  - UT:000377899800001
  dct_language: eng
  dct_publisher: Nature Publishing Group@
  dct_title: Mitochondrial uncouplers inhibit clathrin-mediated endocytosis largely
    through cytoplasmic acidification@
...