article published yes José Guzmán author 30CC5506-F248-11E8-B48F-1D18A9856A870000-0003-2209-5242 Alois Schlögl author 45BF87EE-F248-11E8-B48F-1D18A9856A870000-0002-5621-8100 Michael Frotscher author Peter M Jonas author 353C1B58-F248-11E8-B48F-1D18A9856A870000-0001-5001-4804 ScienComp department PeJo department Nanophysiology of fast-spiking, parvalbumin-expressing GABAergic interneurons project Mechanisms of transmitter release at GABAergic synapses project The hippocampal CA3 region plays a key role in learning and memory. Recurrent CA3–CA3 synapses are thought to be the subcellular substrate of pattern completion. However, the synaptic mechanisms of this network computation remain enigmatic. To investigate these mechanisms, we combined functional connectivity analysis with network modeling. Simultaneous recording fromup to eight CA3 pyramidal neurons revealed that connectivity was sparse, spatially uniform, and highly enriched in disynaptic motifs (reciprocal, convergence,divergence, and chain motifs). Unitary connections were composed of one or two synaptic contacts, suggesting efficient use of postsynaptic space. Real-size modeling indicated that CA3 networks with sparse connectivity, disynaptic motifs, and single-contact connections robustly generated pattern completion.Thus, macro- and microconnectivity contribute to efficient memory storage and retrieval in hippocampal networks. https://research-explorer.ista.ac.at/download/1350/4945/IST-2017-823-v1+1_aaf1836_CombinedPDF_v2-1.pdf application/pdfno American Association for the Advancement of Science2016 eng 00038262680004510.1126/science.aaf1836 35363041117 - 1123 J. Guzmán, A. Schlögl, M. Frotscher, P.M. Jonas, Science 353 (2016) 1117–1123. Guzmán, J., Schlögl, A., Frotscher, M., &#38; Jonas, P. M. (2016). Synaptic mechanisms of pattern completion in the hippocampal CA3 network. <i>Science</i>. American Association for the Advancement of Science. <a href="https://doi.org/10.1126/science.aaf1836">https://doi.org/10.1126/science.aaf1836</a> Guzmán J, Schlögl A, Frotscher M, Jonas PM. Synaptic mechanisms of pattern completion in the hippocampal CA3 network. <i>Science</i>. 2016;353(6304):1117-1123. doi:<a href="https://doi.org/10.1126/science.aaf1836">10.1126/science.aaf1836</a> Guzmán, José, Alois Schlögl, Michael Frotscher, and Peter M Jonas. “Synaptic Mechanisms of Pattern Completion in the Hippocampal CA3 Network.” <i>Science</i>. American Association for the Advancement of Science, 2016. <a href="https://doi.org/10.1126/science.aaf1836">https://doi.org/10.1126/science.aaf1836</a>. J. Guzmán, A. Schlögl, M. Frotscher, and P. M. Jonas, “Synaptic mechanisms of pattern completion in the hippocampal CA3 network,” <i>Science</i>, vol. 353, no. 6304. American Association for the Advancement of Science, pp. 1117–1123, 2016. Guzmán J, Schlögl A, Frotscher M, Jonas PM. 2016. Synaptic mechanisms of pattern completion in the hippocampal CA3 network. Science. 353(6304), 1117–1123. Guzmán, José, et al. “Synaptic Mechanisms of Pattern Completion in the Hippocampal CA3 Network.” <i>Science</i>, vol. 353, no. 6304, American Association for the Advancement of Science, 2016, pp. 1117–23, doi:<a href="https://doi.org/10.1126/science.aaf1836">10.1126/science.aaf1836</a>. 13502018-12-11T11:51:31Z2025-09-22T08:12:10Z