---
_id: '1350'
abstract:
- lang: eng
  text: "The hippocampal CA3 region plays a key role in learning and memory. Recurrent
    CA3–CA3\r\nsynapses are thought to be the subcellular substrate of pattern completion.
    However, the\r\nsynaptic mechanisms of this network computation remain enigmatic.
    To investigate these mechanisms, we combined functional connectivity analysis
    with network modeling.\r\nSimultaneous recording fromup to eight CA3 pyramidal
    neurons revealed that connectivity was sparse, spatially uniform, and highly enriched
    in disynaptic motifs (reciprocal, convergence,divergence, and chain motifs). Unitary
    connections were composed of one or two synaptic contacts, suggesting efficient
    use of postsynaptic space. Real-size modeling indicated that CA3 networks with
    sparse connectivity, disynaptic motifs, and single-contact connections robustly
    generated pattern completion.Thus, macro- and microconnectivity contribute to
    efficient\r\nmemory storage and retrieval in hippocampal networks."
acknowledged_ssus:
- _id: ScienComp
article_processing_charge: No
author:
- first_name: José
  full_name: Guzmán, José
  id: 30CC5506-F248-11E8-B48F-1D18A9856A87
  last_name: Guzmán
  orcid: 0000-0003-2209-5242
- first_name: Alois
  full_name: Schlögl, Alois
  id: 45BF87EE-F248-11E8-B48F-1D18A9856A87
  last_name: Schlögl
  orcid: 0000-0002-5621-8100
- first_name: Michael
  full_name: Frotscher, Michael
  last_name: Frotscher
- first_name: Peter M
  full_name: Jonas, Peter M
  id: 353C1B58-F248-11E8-B48F-1D18A9856A87
  last_name: Jonas
  orcid: 0000-0001-5001-4804
citation:
  ama: Guzmán J, Schlögl A, Frotscher M, Jonas PM. Synaptic mechanisms of pattern
    completion in the hippocampal CA3 network. <i>Science</i>. 2016;353(6304):1117-1123.
    doi:<a href="https://doi.org/10.1126/science.aaf1836">10.1126/science.aaf1836</a>
  apa: Guzmán, J., Schlögl, A., Frotscher, M., &#38; Jonas, P. M. (2016). Synaptic
    mechanisms of pattern completion in the hippocampal CA3 network. <i>Science</i>.
    American Association for the Advancement of Science. <a href="https://doi.org/10.1126/science.aaf1836">https://doi.org/10.1126/science.aaf1836</a>
  chicago: Guzmán, José, Alois Schlögl, Michael Frotscher, and Peter M Jonas. “Synaptic
    Mechanisms of Pattern Completion in the Hippocampal CA3 Network.” <i>Science</i>.
    American Association for the Advancement of Science, 2016. <a href="https://doi.org/10.1126/science.aaf1836">https://doi.org/10.1126/science.aaf1836</a>.
  ieee: J. Guzmán, A. Schlögl, M. Frotscher, and P. M. Jonas, “Synaptic mechanisms
    of pattern completion in the hippocampal CA3 network,” <i>Science</i>, vol. 353,
    no. 6304. American Association for the Advancement of Science, pp. 1117–1123,
    2016.
  ista: Guzmán J, Schlögl A, Frotscher M, Jonas PM. 2016. Synaptic mechanisms of pattern
    completion in the hippocampal CA3 network. Science. 353(6304), 1117–1123.
  mla: Guzmán, José, et al. “Synaptic Mechanisms of Pattern Completion in the Hippocampal
    CA3 Network.” <i>Science</i>, vol. 353, no. 6304, American Association for the
    Advancement of Science, 2016, pp. 1117–23, doi:<a href="https://doi.org/10.1126/science.aaf1836">10.1126/science.aaf1836</a>.
  short: J. Guzmán, A. Schlögl, M. Frotscher, P.M. Jonas, Science 353 (2016) 1117–1123.
corr_author: '1'
date_created: 2018-12-11T11:51:31Z
date_published: 2016-09-09T00:00:00Z
date_updated: 2025-09-22T08:12:10Z
day: '09'
ddc:
- '570'
department:
- _id: ScienComp
- _id: PeJo
doi: 10.1126/science.aaf1836
ec_funded: 1
external_id:
  isi:
  - '000382626800045'
file:
- access_level: open_access
  checksum: 89caefa4e181424cbf0aecc835fcc5ec
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:12:27Z
  date_updated: 2020-07-14T12:44:46Z
  file_id: '4945'
  file_name: IST-2017-823-v1+1_aaf1836_CombinedPDF_v2-1.pdf
  file_size: 19408143
  relation: main_file
file_date_updated: 2020-07-14T12:44:46Z
has_accepted_license: '1'
intvolume: '       353'
isi: 1
issue: '6304'
language:
- iso: eng
month: '09'
oa: 1
oa_version: Preprint
page: 1117 - 1123
project:
- _id: 25C0F108-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '268548'
  name: Nanophysiology of fast-spiking, parvalbumin-expressing GABAergic interneurons
- _id: 25C26B1E-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: P24909-B24
  name: Mechanisms of transmitter release at GABAergic synapses
publication: Science
publication_status: published
publisher: American Association for the Advancement of Science
publist_id: '5899'
pubrep_id: '823'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Synaptic mechanisms of pattern completion in the hippocampal CA3 network
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 353
year: '2016'
...