---
res:
bibo_abstract:
- "The role of gene interactions in the evolutionary process has long\r\nbeen controversial.
Although some argue that they are not of\r\nimportance, because most variation
is additive, others claim that\r\ntheir effect in the long term can be substantial.
Here, we focus on\r\nthe long-term effects of genetic interactions under directional\r\nselection
assuming no mutation or dominance, and that epistasis is\r\nsymmetrical overall.
We ask by how much the mean of a complex\r\ntrait can be increased by selection
and analyze two extreme\r\nregimes, in which either drift or selection dominate
the dynamics\r\nof allele frequencies. In both scenarios, epistatic interactions
affect\r\nthe long-term response to selection by modulating the additive\r\ngenetic
variance. When drift dominates, we extend Robertson\r\n’\r\ns\r\n[Robertson A
(1960)\r\nProc R Soc Lond B Biol Sci\r\n153(951):234\r\n−\r\n249]\r\nargument
to show that, for any form of epistasis, the total response\r\nof a haploid population
is proportional to the initial total genotypic\r\nvariance. In contrast, the total
response of a diploid population is\r\nincreased by epistasis, for a given initial
genotypic variance. When\r\nselection dominates, we show that the total selection
response can\r\nonly be increased by epistasis when s\r\nome initially deleterious
alleles\r\nbecome favored as the genetic background changes. We find a sim-\r\nple
approximation for this effect and show that, in this regime, it is\r\nthe structure
of the genotype - phenotype map that matters and not\r\nthe variance components
of the population.@eng"
bibo_authorlist:
- foaf_Person:
foaf_givenName: Tiago
foaf_name: Paixao, Tiago
foaf_surname: Paixao
foaf_workInfoHomepage: http://www.librecat.org/personId=2C5658E6-F248-11E8-B48F-1D18A9856A87
orcid: 0000-0003-2361-3953
- foaf_Person:
foaf_givenName: Nicholas H
foaf_name: Barton, Nicholas H
foaf_surname: Barton
foaf_workInfoHomepage: http://www.librecat.org/personId=4880FE40-F248-11E8-B48F-1D18A9856A87
orcid: 0000-0002-8548-5240
bibo_doi: 10.1073/pnas.1518830113
bibo_issue: '16'
bibo_volume: 113
dct_date: 2016^xs_gYear
dct_language: eng
dct_publisher: National Academy of Sciences@
dct_title: The effect of gene interactions on the long-term response to selection@
fabio_hasPubmedId: '27044080'
...