article published yes Nela Nikolic author 42D9CABC-F248-11E8-B48F-1D18A9856A870000-0001-9068-6090 CaGu department International IST Postdoc Fellowship Programme project Autoregulation is the direct modulation of gene expression by the product of the corresponding gene. Autoregulation of bacterial gene expression has been mostly studied at the transcriptional level, when a protein acts as the cognate transcriptional repressor. A recent study investigating dynamics of the bacterial toxin–antitoxin MazEF system has shown how autoregulation at both the transcriptional and post-transcriptional levels affects the heterogeneity of Escherichia coli populations. Toxin–antitoxin systems hold a crucial but still elusive part in bacterial response to stress. This perspective highlights how these modules can also serve as a great model system for investigating basic concepts in gene regulation. However, as the genomic background and environmental conditions substantially influence toxin activation, it is important to study (auto)regulation of toxin–antitoxin systems in well-defined setups as well as in conditions that resemble the environmental niche. https://research-explorer.ista.ac.at/download/138/5930/2019_CurrentGenetics_Nikolic.pdf application/pdfno https://creativecommons.org/licenses/by/4.0/ Springer2019 eng 00045695880001710.1007/s00294-018-0879-8 651133-138 Nikolic N. 2019. Autoregulation of bacterial gene expression: lessons from the MazEF toxin–antitoxin system. Current Genetics. 65(1), 133–138. N. Nikolic, “Autoregulation of bacterial gene expression: lessons from the MazEF toxin–antitoxin system,” <i>Current Genetics</i>, vol. 65, no. 1. Springer, pp. 133–138, 2019. Nikolic N. Autoregulation of bacterial gene expression: lessons from the MazEF toxin–antitoxin system. <i>Current Genetics</i>. 2019;65(1):133-138. doi:<a href="https://doi.org/10.1007/s00294-018-0879-8">10.1007/s00294-018-0879-8</a> N. Nikolic, Current Genetics 65 (2019) 133–138. Nikolic, Nela. “Autoregulation of Bacterial Gene Expression: Lessons from the MazEF Toxin–Antitoxin System.” <i>Current Genetics</i>, vol. 65, no. 1, Springer, 2019, pp. 133–38, doi:<a href="https://doi.org/10.1007/s00294-018-0879-8">10.1007/s00294-018-0879-8</a>. Nikolic, Nela. “Autoregulation of Bacterial Gene Expression: Lessons from the MazEF Toxin–Antitoxin System.” <i>Current Genetics</i>. Springer, 2019. <a href="https://doi.org/10.1007/s00294-018-0879-8">https://doi.org/10.1007/s00294-018-0879-8</a>. Nikolic, N. (2019). Autoregulation of bacterial gene expression: lessons from the MazEF toxin–antitoxin system. <i>Current Genetics</i>. Springer. <a href="https://doi.org/10.1007/s00294-018-0879-8">https://doi.org/10.1007/s00294-018-0879-8</a> 1382018-12-11T11:44:50Z2025-04-15T06:50:19Z