---
res:
  bibo_abstract:
  - CA3 pyramidal neurons are thought to pay a key role in memory storage and pattern
    completion by activity-dependent synaptic plasticity between CA3-CA3 recurrent
    excitatory synapses. To examine the induction rules of synaptic plasticity at
    CA3-CA3 synapses, we performed whole-cell patch-clamp recordings in acute hippocampal
    slices from rats (postnatal 21-24 days) at room temperature. Compound excitatory
    postsynaptic potentials (ESPSs) were recorded by tract stimulation in stratum
    oriens in the presence of 10 µM gabazine. High-frequency stimulation (HFS) induced
    N-methyl-D-aspartate (NMDA) receptor-dependent long-term potentiation (LTP). Although
    LTP by HFS did not requier postsynaptic spikes, it was blocked by Na+-channel
    blockers suggesting that local active processes (e.g.) dendritic spikes) may contribute
    to LTP induction without requirement of a somatic action potential (AP). We next
    examined the properties of spike timing-dependent plasticity (STDP) at CA3-CA3
    synapses. Unexpectedly, low-frequency pairing of EPSPs and backpropagated action
    potentialy (bAPs) induced LTP, independent of temporal order. The STDP curve was
    symmetric and broad, with a half-width of ~150 ms. Consistent with these specific
    STDP induction properties, post-presynaptic sequences led to a supralinear summation
    of spine [Ca2+] transients. Furthermore, in autoassociative network models, storage
    and recall was substantially more robust with symmetric than with asymmetric STDP
    rules. In conclusion, we found associative forms of LTP at CA3-CA3 recurrent collateral
    synapses with distinct induction rules. LTP induced by HFS may be associated with
    dendritic spikes. In contrast, low frequency pairing of pre- and postsynaptic
    activity induced LTP only if EPSP-AP were temporally very close. Together, these
    induction mechanisms of synaptiic plasticity may contribute to memory storage
    in the CA3-CA3 microcircuit at different ranges of activity.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Rajiv Kumar
      foaf_name: Mishra, Rajiv Kumar
      foaf_surname: Mishra
      foaf_workInfoHomepage: http://www.librecat.org/personId=46CB58F2-F248-11E8-B48F-1D18A9856A87
  dct_date: 2016^xs_gYear
  dct_isPartOf:
  - http://id.crossref.org/issn/2663-337X
  dct_language: eng
  dct_publisher: Institute of Science and Technology Austria@
  dct_title: Synaptic plasticity rules at CA3-CA3 recurrent synapses in hippocampus@
...