---
OA_place: publisher
_id: '1396'
abstract:
- lang: eng
  text: CA3 pyramidal neurons are thought to pay a key role in memory storage and
    pattern completion by activity-dependent synaptic plasticity between CA3-CA3 recurrent
    excitatory synapses. To examine the induction rules of synaptic plasticity at
    CA3-CA3 synapses, we performed whole-cell patch-clamp recordings in acute hippocampal
    slices from rats (postnatal 21-24 days) at room temperature. Compound excitatory
    postsynaptic potentials (ESPSs) were recorded by tract stimulation in stratum
    oriens in the presence of 10 µM gabazine. High-frequency stimulation (HFS) induced
    N-methyl-D-aspartate (NMDA) receptor-dependent long-term potentiation (LTP). Although
    LTP by HFS did not requier postsynaptic spikes, it was blocked by Na+-channel
    blockers suggesting that local active processes (e.g.) dendritic spikes) may contribute
    to LTP induction without requirement of a somatic action potential (AP). We next
    examined the properties of spike timing-dependent plasticity (STDP) at CA3-CA3
    synapses. Unexpectedly, low-frequency pairing of EPSPs and backpropagated action
    potentialy (bAPs) induced LTP, independent of temporal order. The STDP curve was
    symmetric and broad, with a half-width of ~150 ms. Consistent with these specific
    STDP induction properties, post-presynaptic sequences led to a supralinear summation
    of spine [Ca2+] transients. Furthermore, in autoassociative network models, storage
    and recall was substantially more robust with symmetric than with asymmetric STDP
    rules. In conclusion, we found associative forms of LTP at CA3-CA3 recurrent collateral
    synapses with distinct induction rules. LTP induced by HFS may be associated with
    dendritic spikes. In contrast, low frequency pairing of pre- and postsynaptic
    activity induced LTP only if EPSP-AP were temporally very close. Together, these
    induction mechanisms of synaptiic plasticity may contribute to memory storage
    in the CA3-CA3 microcircuit at different ranges of activity.
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Rajiv Kumar
  full_name: Mishra, Rajiv Kumar
  id: 46CB58F2-F248-11E8-B48F-1D18A9856A87
  last_name: Mishra
citation:
  ama: Mishra RK. Synaptic plasticity rules at CA3-CA3 recurrent synapses in hippocampus.
    2016.
  apa: Mishra, R. K. (2016). <i>Synaptic plasticity rules at CA3-CA3 recurrent synapses
    in hippocampus</i>. Institute of Science and Technology Austria.
  chicago: Mishra, Rajiv Kumar. “Synaptic Plasticity Rules at CA3-CA3 Recurrent Synapses
    in Hippocampus.” Institute of Science and Technology Austria, 2016.
  ieee: R. K. Mishra, “Synaptic plasticity rules at CA3-CA3 recurrent synapses in
    hippocampus,” Institute of Science and Technology Austria, 2016.
  ista: Mishra RK. 2016. Synaptic plasticity rules at CA3-CA3 recurrent synapses in
    hippocampus. Institute of Science and Technology Austria.
  mla: Mishra, Rajiv Kumar. <i>Synaptic Plasticity Rules at CA3-CA3 Recurrent Synapses
    in Hippocampus</i>. Institute of Science and Technology Austria, 2016.
  short: R.K. Mishra, Synaptic Plasticity Rules at CA3-CA3 Recurrent Synapses in Hippocampus,
    Institute of Science and Technology Austria, 2016.
corr_author: '1'
date_created: 2018-12-11T11:51:46Z
date_published: 2016-03-01T00:00:00Z
date_updated: 2026-07-29T11:31:52Z
day: '01'
ddc:
- '570'
degree_awarded: PhD
department:
- _id: PeJo
- _id: GradSch
doi_confirm: '1'
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  date_created: 2019-08-09T12:14:46Z
  date_updated: 2020-07-14T12:44:48Z
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has_accepted_license: '1'
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
page: '83'
publication_identifier:
  issn:
  - 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
publist_id: '5811'
related_material:
  record:
  - id: '1432'
    relation: part_of_dissertation
    status: public
status: public
supervisor:
- first_name: Peter M
  full_name: Jonas, Peter M
  id: 353C1B58-F248-11E8-B48F-1D18A9856A87
  last_name: Jonas
  orcid: 0000-0001-5001-4804
title: Synaptic plasticity rules at CA3-CA3 recurrent synapses in hippocampus
type: dissertation
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2016'
...