---
_id: '14003'
abstract:
- lang: eng
  text: "Molecular chirality plays an essential role in most biochemical processes.
    The observation and quantification of chirality-sensitive signals, however, remains
    extremely challenging, especially on ultrafast timescales and in dilute media.
    Here, we describe the experimental realization of an all-optical and ultrafast
    scheme for detecting chiral dynamics in molecules. This technique is based on
    high-harmonic generation by a combination of two-color counterrotating femtosecond
    laser pulses with polarization states tunable from linear to circular. We demonstrate
    two different implementations of chiral-sensitive high-harmonic spectroscopy on
    an ensemble of randomly oriented methyloxirane molecules in the gas phase. Using
    two elliptically polarized fields, we observe that the ellipticities maximizing
    the harmonic signal reach up to \r\n4.4\r\n±\r\n0.2\r\n%\r\n (at 17.6 eV). Using
    two circularly polarized fields, we observe circular dichroisms ranging up to
    \r\n13\r\n±\r\n6\r\n%\r\n (28.3–33.1 eV). Our theoretical analysis confirms that
    the observed chiral response originates from subfemtosecond electron dynamics
    driven by the magnetic component of the driving laser field. This assignment is
    supported by the experimental observation of a strong intensity dependence of
    the chiral effects and its agreement with theory. We moreover report and explain
    a pronounced variation of the signal strength and dichroism with the driving-field
    ellipticities and harmonic orders. Finally, we demonstrate the sensitivity of
    the experimental observables to the shape of the electron hole. This technique
    for chiral discrimination will yield femtosecond temporal resolution when integrated
    in a pump-probe scheme and subfemtosecond resolution on chiral charge migration
    in a self-probing scheme."
article_number: '031060'
article_processing_charge: No
article_type: original
author:
- first_name: Denitsa Rangelova
  full_name: Baykusheva, Denitsa Rangelova
  id: 71b4d059-2a03-11ee-914d-dfa3beed6530
  last_name: Baykusheva
- first_name: Hans Jakob
  full_name: Wörner, Hans Jakob
  last_name: Wörner
citation:
  ama: Baykusheva DR, Wörner HJ. Chiral discrimination through bielliptical high-harmonic
    spectroscopy. <i>Physical Review X</i>. 2018;8(3). doi:<a href="https://doi.org/10.1103/physrevx.8.031060">10.1103/physrevx.8.031060</a>
  apa: Baykusheva, D. R., &#38; Wörner, H. J. (2018). Chiral discrimination through
    bielliptical high-harmonic spectroscopy. <i>Physical Review X</i>. American Physical
    Society. <a href="https://doi.org/10.1103/physrevx.8.031060">https://doi.org/10.1103/physrevx.8.031060</a>
  chicago: Baykusheva, Denitsa Rangelova, and Hans Jakob Wörner. “Chiral Discrimination
    through Bielliptical High-Harmonic Spectroscopy.” <i>Physical Review X</i>. American
    Physical Society, 2018. <a href="https://doi.org/10.1103/physrevx.8.031060">https://doi.org/10.1103/physrevx.8.031060</a>.
  ieee: D. R. Baykusheva and H. J. Wörner, “Chiral discrimination through bielliptical
    high-harmonic spectroscopy,” <i>Physical Review X</i>, vol. 8, no. 3. American
    Physical Society, 2018.
  ista: Baykusheva DR, Wörner HJ. 2018. Chiral discrimination through bielliptical
    high-harmonic spectroscopy. Physical Review X. 8(3), 031060.
  mla: Baykusheva, Denitsa Rangelova, and Hans Jakob Wörner. “Chiral Discrimination
    through Bielliptical High-Harmonic Spectroscopy.” <i>Physical Review X</i>, vol.
    8, no. 3, 031060, American Physical Society, 2018, doi:<a href="https://doi.org/10.1103/physrevx.8.031060">10.1103/physrevx.8.031060</a>.
  short: D.R. Baykusheva, H.J. Wörner, Physical Review X 8 (2018).
date_created: 2023-08-10T06:34:48Z
date_published: 2018-07-01T00:00:00Z
date_updated: 2023-08-22T07:42:07Z
day: '01'
doi: 10.1103/physrevx.8.031060
extern: '1'
intvolume: '         8'
issue: '3'
keyword:
- General Physics and Astronomy
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1103/PhysRevX.8.031060
month: '07'
oa: 1
oa_version: Published Version
publication: Physical Review X
publication_identifier:
  eissn:
  - 2160-3308
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Chiral discrimination through bielliptical high-harmonic spectroscopy
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 8
year: '2018'
...