---
res:
  bibo_abstract:
  - Phosphatidylinositol (Ptdlns) is a structural phospholipid that can be phosphorylated
    into various lipid signaling molecules, designated polyphosphoinositides (PPIs).
    The reversible phosphorylation of PPIs on the 3, 4, or 5 position of inositol
    is performed by a set of organelle-specific kinases and phosphatases, and the
    characteristic head groups make these molecules ideal for regulating biological
    processes in time and space. In yeast and mammals, Ptdlns3P and Ptdlns(3,5)P2
    play crucial roles in trafficking toward the lytic compartments, whereas the role
    in plants is not yet fully understood. Here we identified the role of a land plant-specific
    subgroup of PPI phosphatases, the suppressor of actin 2 (SAC2) to SAC5, during
    vauolar trafficking and morphogenesis in Arabidopsis thaliana. SAC2-SAC5 localize
    to the tonoplast along with Ptdlns3P, the presumable product of their activity.
    in SAC gain- and loss-of-function mutants, the levels of Ptdlns monophosphates
    and bisphosphates were changed, with opposite effects on the morphology of storage
    and lytic vacuoles, and the trafficking toward the vacuoles was defective. Moreover,
    multiple sac knockout mutants had an increased number of smaller storage and lytic
    vacuoles, whereas extralarge vacuoles were observed in the overexpression lines,
    correlating with various growth and developmental defects. The fragmented vacuolar
    phenotype of sac mutants could be mimicked by treating wild-type seedlings with
    Ptdlns(3,5)P2, corroborating that this PPI is important for vacuole morphology.
    Taken together, these results provide evidence that PPIs, together with their
    metabolic enzymes SAC2-SAC5, are crucial for vacuolar trafficking and for vacuolar
    morphology and function in plants.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Petra
      foaf_name: Marhavá, Petra
      foaf_surname: Marhavá
      foaf_workInfoHomepage: http://www.librecat.org/personId=44E59624-F248-11E8-B48F-1D18A9856A87
  dct_date: 2014^xs_gYear
  dct_isPartOf:
  - http://id.crossref.org/issn/2663-337X
  dct_language: eng
  dct_publisher: Institute of Science and Technology Austria@
  dct_title: Molecular mechanisms of patterning and subcellular trafficking in Arabidopsis
    thaliana@
...