article published yes Thomas A. Leonard author Martin Loose author 462D4284-F248-11E8-B48F-1D18A9856A870000-0001-7309-9724 Sascha Martens author MaLo department In vitro reconstitution of bacterial cell division project Synthetic and structural biology of Rab GTPase networks project Membranes are essential for life. They act as semi-permeable boundaries that define cells and organelles. In addition, their surfaces actively participate in biochemical reaction networks, where they confine proteins, align reaction partners, and directly control enzymatic activities. Membrane-localized reactions shape cellular membranes, define the identity of organelles, compartmentalize biochemical processes, and can even be the source of signaling gradients that originate at the plasma membrane and reach into the cytoplasm and nucleus. The membrane surface is, therefore, an essential platform upon which myriad cellular processes are scaffolded. In this review, we summarize our current understanding of the biophysics and biochemistry of membrane-localized reactions with particular focus on insights derived from reconstituted and cellular systems. We discuss how the interplay of cellular factors results in their self-organization, condensation, assembly, and activity, and the emergent properties derived from them. https://research-explorer.ista.ac.at/download/14039/14049/2023_DevelopmentalCell_Leonard.pdf application/pdfno https://creativecommons.org/licenses/by/4.0/ Elsevier2023 eng 1534-5807 1878-1551 37419118 00105911040000110.1016/j.devcel.2023.06.001 58151315-1332 Leonard, Thomas A., Martin Loose, and Sascha Martens. “The Membrane Surface as a Platform That Organizes Cellular and Biochemical Processes.” <i>Developmental Cell</i>. Elsevier, 2023. <a href="https://doi.org/10.1016/j.devcel.2023.06.001">https://doi.org/10.1016/j.devcel.2023.06.001</a>. Leonard TA, Loose M, Martens S. 2023. The membrane surface as a platform that organizes cellular and biochemical processes. Developmental Cell. 58(15), 1315–1332. Leonard TA, Loose M, Martens S. The membrane surface as a platform that organizes cellular and biochemical processes. <i>Developmental Cell</i>. 2023;58(15):1315-1332. doi:<a href="https://doi.org/10.1016/j.devcel.2023.06.001">10.1016/j.devcel.2023.06.001</a> Leonard, T. A., Loose, M., &#38; Martens, S. (2023). The membrane surface as a platform that organizes cellular and biochemical processes. <i>Developmental Cell</i>. Elsevier. <a href="https://doi.org/10.1016/j.devcel.2023.06.001">https://doi.org/10.1016/j.devcel.2023.06.001</a> T.A. Leonard, M. Loose, S. Martens, Developmental Cell 58 (2023) 1315–1332. T. A. Leonard, M. Loose, and S. Martens, “The membrane surface as a platform that organizes cellular and biochemical processes,” <i>Developmental Cell</i>, vol. 58, no. 15. Elsevier, pp. 1315–1332, 2023. Leonard, Thomas A., et al. “The Membrane Surface as a Platform That Organizes Cellular and Biochemical Processes.” <i>Developmental Cell</i>, vol. 58, no. 15, Elsevier, 2023, pp. 1315–32, doi:<a href="https://doi.org/10.1016/j.devcel.2023.06.001">10.1016/j.devcel.2023.06.001</a>. 140392023-08-13T22:01:12Z2024-10-22T11:40:18Z