---
res:
  bibo_abstract:
  - Growth factors and cytokines signal by binding to the extracellular domains of
    their receptors and drive association and transphosphorylation of the receptor
    intracellular tyrosine kinase domains, initiating downstream signaling cascades.
    To enable systematic exploration of how receptor valency and geometry affects
    signaling outcomes, we designed cyclic homo-oligomers with up to 8 subunits using
    repeat protein building blocks that can be modularly extended. By incorporating
    a de novo designed fibroblast growth-factor receptor (FGFR) binding module into
    these scaffolds, we generated a series of synthetic signaling ligands that exhibit
    potent valency- and geometry-dependent Ca2+ release and MAPK pathway activation.
    The high specificity of the designed agonists reveal distinct roles for two FGFR
    splice variants in driving endothelial and mesenchymal cell fates during early
    vascular development. The ability to incorporate receptor binding domains and
    repeat extensions in a modular fashion makes our designed scaffolds broadly useful
    for probing and manipulating cellular signaling pathways.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Natasha I
      foaf_name: Edman, Natasha I
      foaf_surname: Edman
  - foaf_Person:
      foaf_givenName: Rachel L
      foaf_name: Redler, Rachel L
      foaf_surname: Redler
  - foaf_Person:
      foaf_givenName: Ashish
      foaf_name: Phal, Ashish
      foaf_surname: Phal
  - foaf_Person:
      foaf_givenName: Thomas
      foaf_name: Schlichthaerle, Thomas
      foaf_surname: Schlichthaerle
  - foaf_Person:
      foaf_givenName: Sanjay R
      foaf_name: Srivatsan, Sanjay R
      foaf_surname: Srivatsan
  - foaf_Person:
      foaf_givenName: Ali
      foaf_name: Etemadi, Ali
      foaf_surname: Etemadi
  - foaf_Person:
      foaf_givenName: Seong
      foaf_name: An, Seong
      foaf_surname: An
  - foaf_Person:
      foaf_givenName: Andrew
      foaf_name: Favor, Andrew
      foaf_surname: Favor
  - foaf_Person:
      foaf_givenName: Devon
      foaf_name: Ehnes, Devon
      foaf_surname: Ehnes
  - foaf_Person:
      foaf_givenName: Zhe
      foaf_name: Li, Zhe
      foaf_surname: Li
  - foaf_Person:
      foaf_givenName: Florian M
      foaf_name: Praetorius, Florian M
      foaf_surname: Praetorius
      foaf_workInfoHomepage: http://www.librecat.org/personId=dfec9381-4341-11ee-8fd8-faa02bba7d62
  - foaf_Person:
      foaf_givenName: Max
      foaf_name: Gordon, Max
      foaf_surname: Gordon
  - foaf_Person:
      foaf_givenName: Wei
      foaf_name: Yang, Wei
      foaf_surname: Yang
  - foaf_Person:
      foaf_givenName: Brian
      foaf_name: Coventry, Brian
      foaf_surname: Coventry
  - foaf_Person:
      foaf_givenName: Derrick R
      foaf_name: Hicks, Derrick R
      foaf_surname: Hicks
  - foaf_Person:
      foaf_givenName: Longxing
      foaf_name: Cao, Longxing
      foaf_surname: Cao
  - foaf_Person:
      foaf_givenName: Neville
      foaf_name: Bethel, Neville
      foaf_surname: Bethel
  - foaf_Person:
      foaf_givenName: Piper
      foaf_name: Heine, Piper
      foaf_surname: Heine
  - foaf_Person:
      foaf_givenName: Analisa N
      foaf_name: Murray, Analisa N
      foaf_surname: Murray
  - foaf_Person:
      foaf_givenName: Stacey
      foaf_name: Gerben, Stacey
      foaf_surname: Gerben
  - foaf_Person:
      foaf_givenName: Lauren
      foaf_name: Carter, Lauren
      foaf_surname: Carter
  - foaf_Person:
      foaf_givenName: Marcos
      foaf_name: Miranda, Marcos
      foaf_surname: Miranda
  - foaf_Person:
      foaf_givenName: Babak
      foaf_name: Negahdari, Babak
      foaf_surname: Negahdari
  - foaf_Person:
      foaf_givenName: Sangwon
      foaf_name: Lee, Sangwon
      foaf_surname: Lee
  - foaf_Person:
      foaf_givenName: Cole
      foaf_name: Trapnell, Cole
      foaf_surname: Trapnell
  - foaf_Person:
      foaf_givenName: Lance
      foaf_name: Stewart, Lance
      foaf_surname: Stewart
  - foaf_Person:
      foaf_givenName: Damian C
      foaf_name: Ekiert, Damian C
      foaf_surname: Ekiert
  - foaf_Person:
      foaf_givenName: Joseph
      foaf_name: Schlessinger, Joseph
      foaf_surname: Schlessinger
  - foaf_Person:
      foaf_givenName: Jay
      foaf_name: Shendure, Jay
      foaf_surname: Shendure
  - foaf_Person:
      foaf_givenName: Gira
      foaf_name: Bhabha, Gira
      foaf_surname: Bhabha
  - foaf_Person:
      foaf_givenName: Hannele
      foaf_name: Ruohola-Baker, Hannele
      foaf_surname: Ruohola-Baker
  - foaf_Person:
      foaf_givenName: David
      foaf_name: Baker, David
      foaf_surname: Baker
  bibo_doi: 10.1101/2023.03.14.532666
  dct_date: 2023^xs_gYear
  dct_language: eng
  dct_title: Modulation of FGF pathway signaling and vascular differentiation using
    designed oligomeric assemblies@
...