---
_id: '14302'
abstract:
- lang: eng
  text: One key goal of DNA nanotechnology is the bottom-up construction of macroscopic
    crystalline materials. Beyond applications in fields such as photonics or plasmonics,
    DNA-based crystal matrices could possibly facilitate the diffraction-based structural
    analysis of guest molecules. Seeman and co-workers reported in 2009 the first
    designed crystal matrices based on a 38 kDa DNA triangle that was composed of
    seven chains. The crystal lattice was stabilized, unprecedentedly, by Watson–Crick
    base pairing. However, 3D crystallization of larger designed DNA objects that
    include more chains such as DNA origami remains an unsolved problem. Larger objects
    would offer more degrees of freedom and design options with respect to tailoring
    lattice geometry and for positioning other objects within a crystal lattice. The
    greater rigidity of multilayer DNA origami could also positively influence the
    diffractive properties of crystals composed of such particles. Here, we rationally
    explore the role of heterogeneity and Watson–Crick interaction strengths in crystal
    growth using 40 variants of the original DNA triangle as model multichain objects.
    Crystal growth of the triangle was remarkably robust despite massive chemical,
    geometrical, and thermodynamical sample heterogeneity that we introduced, but
    the crystal growth sensitively depended on the sequences of base pairs next to
    the Watson–Crick sticky ends of the triangle. Our results point to weak lattice
    interactions and high concentrations as decisive factors for achieving productive
    crystallization, while sample heterogeneity and impurities played a minor role.
article_processing_charge: No
article_type: original
author:
- first_name: Evi
  full_name: Stahl, Evi
  last_name: Stahl
- first_name: Florian M
  full_name: Praetorius, Florian M
  id: dfec9381-4341-11ee-8fd8-faa02bba7d62
  last_name: Praetorius
- first_name: Carina C.
  full_name: de Oliveira Mann, Carina C.
  last_name: de Oliveira Mann
- first_name: Karl-Peter
  full_name: Hopfner, Karl-Peter
  last_name: Hopfner
- first_name: Hendrik
  full_name: Dietz, Hendrik
  last_name: Dietz
citation:
  ama: Stahl E, Praetorius FM, de Oliveira Mann CC, Hopfner K-P, Dietz H. Impact of
    heterogeneity and lattice bond strength on DNA triangle crystal growth. <i>ACS
    Nano</i>. 2016;10(10):9156-9164. doi:<a href="https://doi.org/10.1021/acsnano.6b04787">10.1021/acsnano.6b04787</a>
  apa: Stahl, E., Praetorius, F. M., de Oliveira Mann, C. C., Hopfner, K.-P., &#38;
    Dietz, H. (2016). Impact of heterogeneity and lattice bond strength on DNA triangle
    crystal growth. <i>ACS Nano</i>. American Chemical Society. <a href="https://doi.org/10.1021/acsnano.6b04787">https://doi.org/10.1021/acsnano.6b04787</a>
  chicago: Stahl, Evi, Florian M Praetorius, Carina C. de Oliveira Mann, Karl-Peter
    Hopfner, and Hendrik Dietz. “Impact of Heterogeneity and Lattice Bond Strength
    on DNA Triangle Crystal Growth.” <i>ACS Nano</i>. American Chemical Society, 2016.
    <a href="https://doi.org/10.1021/acsnano.6b04787">https://doi.org/10.1021/acsnano.6b04787</a>.
  ieee: E. Stahl, F. M. Praetorius, C. C. de Oliveira Mann, K.-P. Hopfner, and H.
    Dietz, “Impact of heterogeneity and lattice bond strength on DNA triangle crystal
    growth,” <i>ACS Nano</i>, vol. 10, no. 10. American Chemical Society, pp. 9156–9164,
    2016.
  ista: Stahl E, Praetorius FM, de Oliveira Mann CC, Hopfner K-P, Dietz H. 2016. Impact
    of heterogeneity and lattice bond strength on DNA triangle crystal growth. ACS
    Nano. 10(10), 9156–9164.
  mla: Stahl, Evi, et al. “Impact of Heterogeneity and Lattice Bond Strength on DNA
    Triangle Crystal Growth.” <i>ACS Nano</i>, vol. 10, no. 10, American Chemical
    Society, 2016, pp. 9156–64, doi:<a href="https://doi.org/10.1021/acsnano.6b04787">10.1021/acsnano.6b04787</a>.
  short: E. Stahl, F.M. Praetorius, C.C. de Oliveira Mann, K.-P. Hopfner, H. Dietz,
    ACS Nano 10 (2016) 9156–9164.
date_created: 2023-09-06T12:52:00Z
date_published: 2016-09-01T00:00:00Z
date_updated: 2023-11-07T12:08:46Z
day: '01'
doi: 10.1021/acsnano.6b04787
extern: '1'
external_id:
  pmid:
  - '27583560'
intvolume: '        10'
issue: '10'
language:
- iso: eng
month: '09'
oa_version: None
page: 9156-9164
pmid: 1
publication: ACS Nano
publication_identifier:
  eissn:
  - 1936-086X
  issn:
  - 1936-0851
publication_status: published
publisher: American Chemical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Impact of heterogeneity and lattice bond strength on DNA triangle crystal growth
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 10
year: '2016'
...