---
res:
  bibo_abstract:
  - "Mutation rates represent the net result of complex interactions among various\r\ncellular
    processes and can dramatically influence the evolutionary fate of\r\nmicrobial
    populations. However, many popular techniques used to study\r\nmutations are subject
    to the confounding effects of heredity and the subtleties\r\nof adaptation to
    selection, all of which make it difficult to observe any dynamic\r\nresponses
    of mutation rates to fitness challenges. Furthermore, in spite of the\r\nubiquity
    of quorum sensing systems across the bacterial domain and relevance\r\nfor many
    physiological behaviors, the effects of such mechanisms on mutation\r\nrate and
    adaptation remain poorly understood. In the following work, I\r\npresent the development
    of a microfluidic droplet-based method to measure\r\nsingle base-pair mutation
    rates in growing populations of the bacterium\r\nEscherichia coli. I use this
    method to observe a stress-induced increase in\r\nmutation rate that is mediated
    by luxS, a highly conserved bacterial quorum\r\nsensing component. I also show
    that the aforementioned increase in mutation\r\nrate, and its associated control
    by luxS, corresponds to a higher degree of\r\nadaptability under competitive environments.@eng"
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Mike
      foaf_name: Hennessey-Wesen, Mike
      foaf_surname: Hennessey-Wesen
      foaf_workInfoHomepage: http://www.librecat.org/personId=3F338C72-F248-11E8-B48F-1D18A9856A87
  bibo_doi: 10.15479/at:ista:14641
  dct_date: 2023^xs_gYear
  dct_isPartOf:
  - http://id.crossref.org/issn/2663-337X
  dct_language: eng
  dct_publisher: Institute of Science and Technology Austria@
  dct_subject:
  - microfluidics
  - miceobiology
  - mutations
  - quorum sensing
  dct_title: Adaptive mutation in E. coli modulated by luxS@
...