article published yes Valerio Sorichetti author ef8a92cb-c7b6-11ec-8bea-e1fd5847bc5b0000-0002-9645-6576 Martin Lenz author AnSa department The kinetics of the assembly of semiflexible filaments through end-to-end annealing is key to the structure of the cytoskeleton, but is not understood. We analyze this problem through scaling theory and simulations, and uncover a regime where filaments’ ends find each other through bending fluctuations without the need for the whole filament to diffuse. This results in a very substantial speedup of assembly in physiological regimes, and could help with understanding the dynamics of actin and intermediate filaments in biological processes such as wound healing and cell division. American Physical Society2023 eng 0031-9007 1079-7114 2303.03088 38101392 00116381020000810.1103/PhysRevLett.131.228401 13122 Sorichetti, Valerio, and Martin Lenz. “Transverse Fluctuations Control the Assembly of Semiflexible Filaments.” <i>Physical Review Letters</i>. American Physical Society, 2023. <a href="https://doi.org/10.1103/PhysRevLett.131.228401">https://doi.org/10.1103/PhysRevLett.131.228401</a>. Sorichetti V, Lenz M. Transverse fluctuations control the assembly of semiflexible filaments. <i>Physical Review Letters</i>. 2023;131(22). doi:<a href="https://doi.org/10.1103/PhysRevLett.131.228401">10.1103/PhysRevLett.131.228401</a> Sorichetti V, Lenz M. 2023. Transverse fluctuations control the assembly of semiflexible filaments. Physical Review Letters. 131(22), 228401. Sorichetti, V., &#38; Lenz, M. (2023). Transverse fluctuations control the assembly of semiflexible filaments. <i>Physical Review Letters</i>. American Physical Society. <a href="https://doi.org/10.1103/PhysRevLett.131.228401">https://doi.org/10.1103/PhysRevLett.131.228401</a> Sorichetti, Valerio, and Martin Lenz. “Transverse Fluctuations Control the Assembly of Semiflexible Filaments.” <i>Physical Review Letters</i>, vol. 131, no. 22, 228401, American Physical Society, 2023, doi:<a href="https://doi.org/10.1103/PhysRevLett.131.228401">10.1103/PhysRevLett.131.228401</a>. V. Sorichetti, M. Lenz, Physical Review Letters 131 (2023). V. Sorichetti and M. Lenz, “Transverse fluctuations control the assembly of semiflexible filaments,” <i>Physical Review Letters</i>, vol. 131, no. 22. American Physical Society, 2023. 146552023-12-10T23:00:57Z2025-09-09T13:35:06Z