---
_id: '14655'
abstract:
- lang: eng
  text: The kinetics of the assembly of semiflexible filaments through end-to-end
    annealing is key to the structure of the cytoskeleton, but is not understood.
    We analyze this problem through scaling theory and simulations, and uncover a
    regime where filaments’ ends find each other through bending fluctuations without
    the need for the whole filament to diffuse. This results in a very substantial
    speedup of assembly in physiological regimes, and could help with understanding
    the dynamics of actin and intermediate filaments in biological processes such
    as wound healing and cell division.
acknowledgement: The authors thank C´ecile Leduc and Duc-Quang Tran for invaluable
  help with understanding the experimental behavior of intermediate filaments, and
  Raphael Voituriez, Nicolas Levernier, and Alexander Grosberg for fruitful discussion
  on the theoretical model. V. S. also thanks Davide Michieletto, Maria Panoukidou,
  and Lorenzo Rovigatti for very helpful suggestions on the simulation model. M. L.
  was supported by Marie Curie Integration Grant No. PCIG12-GA-2012-334053, “Investissements
  d’Avenir” LabEx PALM (ANR-10-LABX- 0039-PALM), ANR Grants No. ANR-15-CE13-0004-03,
  No. ANR-21-CE11-0004-02 and No. ANR-22-CE30-0024, as well as ERC Starting Grant
  No. 677532. M.L.’s group belongs to the CNRS consortium AQV. Part of this work was
  performed using HPC resources from GENCI–IDRIS (Grants No. 2020-A0090712066 and
  No. 2021-A0110712066).
article_number: '228401'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Valerio
  full_name: Sorichetti, Valerio
  id: ef8a92cb-c7b6-11ec-8bea-e1fd5847bc5b
  last_name: Sorichetti
  orcid: 0000-0002-9645-6576
- first_name: Martin
  full_name: Lenz, Martin
  last_name: Lenz
citation:
  ama: Sorichetti V, Lenz M. Transverse fluctuations control the assembly of semiflexible
    filaments. <i>Physical Review Letters</i>. 2023;131(22). doi:<a href="https://doi.org/10.1103/PhysRevLett.131.228401">10.1103/PhysRevLett.131.228401</a>
  apa: Sorichetti, V., &#38; Lenz, M. (2023). Transverse fluctuations control the
    assembly of semiflexible filaments. <i>Physical Review Letters</i>. American Physical
    Society. <a href="https://doi.org/10.1103/PhysRevLett.131.228401">https://doi.org/10.1103/PhysRevLett.131.228401</a>
  chicago: Sorichetti, Valerio, and Martin Lenz. “Transverse Fluctuations Control
    the Assembly of Semiflexible Filaments.” <i>Physical Review Letters</i>. American
    Physical Society, 2023. <a href="https://doi.org/10.1103/PhysRevLett.131.228401">https://doi.org/10.1103/PhysRevLett.131.228401</a>.
  ieee: V. Sorichetti and M. Lenz, “Transverse fluctuations control the assembly of
    semiflexible filaments,” <i>Physical Review Letters</i>, vol. 131, no. 22. American
    Physical Society, 2023.
  ista: Sorichetti V, Lenz M. 2023. Transverse fluctuations control the assembly of
    semiflexible filaments. Physical Review Letters. 131(22), 228401.
  mla: Sorichetti, Valerio, and Martin Lenz. “Transverse Fluctuations Control the
    Assembly of Semiflexible Filaments.” <i>Physical Review Letters</i>, vol. 131,
    no. 22, 228401, American Physical Society, 2023, doi:<a href="https://doi.org/10.1103/PhysRevLett.131.228401">10.1103/PhysRevLett.131.228401</a>.
  short: V. Sorichetti, M. Lenz, Physical Review Letters 131 (2023).
corr_author: '1'
date_created: 2023-12-10T23:00:57Z
date_published: 2023-12-01T00:00:00Z
date_updated: 2025-09-09T13:35:06Z
day: '01'
department:
- _id: AnSa
doi: 10.1103/PhysRevLett.131.228401
external_id:
  arxiv:
  - '2303.03088'
  isi:
  - '001163810200008'
  pmid:
  - '38101392'
intvolume: '       131'
isi: 1
issue: '22'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.48550/arXiv.2303.03088
month: '12'
oa: 1
oa_version: Preprint
pmid: 1
publication: Physical Review Letters
publication_identifier:
  eissn:
  - 1079-7114
  issn:
  - 0031-9007
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Transverse fluctuations control the assembly of semiflexible filaments
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 131
year: '2023'
...