---
res:
  bibo_abstract:
  - So-called spontaneous activity is a central hallmark of most nervous systems.
    Such non-causal firing is contrary to the tenet of spikes as a means of communication,
    and its purpose remains unclear. We propose that self-initiated firing can serve
    as a release valve to protect neurons from the toxic conditions arising in mitochondria
    from lower-than-baseline energy consumption. To demonstrate the viability of our
    hypothesis, we built a set of models that incorporate recent experimental results
    indicating homeostatic control of metabolic products—Adenosine triphosphate (ATP),
    adenosine diphosphate (ADP), and reactive oxygen species (ROS)—by changes in firing.
    We explore the relationship of metabolic cost of spiking with its effect on the
    temporal patterning of spikes and reproduce experimentally observed changes in
    intrinsic firing in the fruitfly dorsal fan-shaped body neuron in a model with
    ROS-modulated potassium channels. We also show that metabolic spiking homeostasis
    can produce indefinitely sustained avalanche dynamics in cortical circuits. Our
    theory can account for key features of neuronal activity observed in many studies
    ranging from ion channel function all the way to resting state dynamics. We finish
    with a set of experimental predictions that would confirm an integrated, crucial
    role for metabolically regulated spiking and firmly link metabolic homeostasis
    and neuronal function.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Chaitanya
      foaf_name: Chintaluri, Chaitanya
      foaf_surname: Chintaluri
      foaf_workInfoHomepage: http://www.librecat.org/personId=E4EDB536-3485-11EA-98D2-20AF3DDC885E
  - foaf_Person:
      foaf_givenName: Tim P
      foaf_name: Vogels, Tim P
      foaf_surname: Vogels
      foaf_workInfoHomepage: http://www.librecat.org/personId=CB6FF8D2-008F-11EA-8E08-2637E6697425
    orcid: 0000-0003-3295-6181
  bibo_doi: 10.1073/pnas.2306525120
  bibo_issue: '48'
  bibo_volume: 120
  dct_date: 2023^xs_gYear
  dct_identifier:
  - UT:001157389000005
  dct_isPartOf:
  - http://id.crossref.org/issn/0027-8424
  - http://id.crossref.org/issn/1091-6490
  dct_language: eng
  dct_publisher: National Academy of Sciences@
  dct_title: Metabolically regulated spiking could serve neuronal energy homeostasis
    and protect from reactive oxygen species@
  fabio_hasPubmedId: '37988463'
...