---
_id: '14742'
abstract:
- lang: eng
  text: "Chromosomal rearrangements (CRs) have been known since almost the beginning
    of genetics.\r\nWhile an important role for CRs in speciation has been suggested,
    evidence primarily stems\r\nfrom theoretical and empirical studies focusing on
    the microevolutionary level (i.e., on taxon\r\npairs where speciation is often
    incomplete). Although the role of CRs in eukaryotic speciation at\r\na macroevolutionary
    level has been supported by associations between species diversity and\r\nrates
    of evolution of CRs across phylogenies, these findings are limited to a restricted
    range of\r\nCRs and taxa. Now that more broadly applicable and precise CR detection
    approaches have\r\nbecome available, we address the challenges in filling some
    of the conceptual and empirical\r\ngaps between micro- and macroevolutionary studies
    on the role of CRs in speciation. We\r\nsynthesize what is known about the macroevolutionary
    impact of CRs and suggest new research avenues to overcome the pitfalls of previous
    studies to gain a more comprehensive understanding of the evolutionary significance
    of CRs in speciation across the tree of life."
acknowledgement: "K.L. was funded by a Swiss National Science Foundation Eccellenza
  project: The evolution of strong reproductive barriers towards the completion of
  speciation (PCEFP3_202869). R.F.\r\nwas funded by an FCT CEEC (Fundação para a Ciênca
  e a Tecnologia, Concurso Estímulo ao\r\nEmprego Científico) contract (2020.00275.
  CEECIND) and by an FCT research project\r\n(PTDC/BIA-EVL/1614/2021). M.R. was funded
  by the Swedish Research Council Vetenskapsrådet (grant number 2021-05243). A.M.W.
  was partly funded by the Norwegian Research Council RCN. We thank Luis Silva for
  his help preparing Figure 1. We are grateful to Maren Wellenreuther, Daniel Bolnick,
  and two anonymous reviewers for their constructive feedback on an earlier version
  of this paper."
article_number: a041447
article_processing_charge: No
article_type: original
author:
- first_name: Kay
  full_name: Lucek, Kay
  last_name: Lucek
- first_name: Mabel D.
  full_name: Giménez, Mabel D.
  last_name: Giménez
- first_name: Mathieu
  full_name: Joron, Mathieu
  last_name: Joron
- first_name: Marina
  full_name: Rafajlović, Marina
  last_name: Rafajlović
- first_name: Jeremy B.
  full_name: Searle, Jeremy B.
  last_name: Searle
- first_name: Nora
  full_name: Walden, Nora
  last_name: Walden
- first_name: Anja M
  full_name: Westram, Anja M
  id: 3C147470-F248-11E8-B48F-1D18A9856A87
  last_name: Westram
  orcid: 0000-0003-1050-4969
- first_name: Rui
  full_name: Faria, Rui
  last_name: Faria
citation:
  ama: 'Lucek K, Giménez MD, Joron M, et al. The impact of chromosomal rearrangements
    in speciation: From micro- to macroevolution. <i>Cold Spring Harbor Perspectives
    in Biology</i>. 2023;15(11). doi:<a href="https://doi.org/10.1101/cshperspect.a041447">10.1101/cshperspect.a041447</a>'
  apa: 'Lucek, K., Giménez, M. D., Joron, M., Rafajlović, M., Searle, J. B., Walden,
    N., … Faria, R. (2023). The impact of chromosomal rearrangements in speciation:
    From micro- to macroevolution. <i>Cold Spring Harbor Perspectives in Biology</i>.
    Cold Spring Harbor Laboratory Press. <a href="https://doi.org/10.1101/cshperspect.a041447">https://doi.org/10.1101/cshperspect.a041447</a>'
  chicago: 'Lucek, Kay, Mabel D. Giménez, Mathieu Joron, Marina Rafajlović, Jeremy
    B. Searle, Nora Walden, Anja M Westram, and Rui Faria. “The Impact of Chromosomal
    Rearrangements in Speciation: From Micro- to Macroevolution.” <i>Cold Spring Harbor
    Perspectives in Biology</i>. Cold Spring Harbor Laboratory Press, 2023. <a href="https://doi.org/10.1101/cshperspect.a041447">https://doi.org/10.1101/cshperspect.a041447</a>.'
  ieee: 'K. Lucek <i>et al.</i>, “The impact of chromosomal rearrangements in speciation:
    From micro- to macroevolution,” <i>Cold Spring Harbor Perspectives in Biology</i>,
    vol. 15, no. 11. Cold Spring Harbor Laboratory Press, 2023.'
  ista: 'Lucek K, Giménez MD, Joron M, Rafajlović M, Searle JB, Walden N, Westram
    AM, Faria R. 2023. The impact of chromosomal rearrangements in speciation: From
    micro- to macroevolution. Cold Spring Harbor Perspectives in Biology. 15(11),
    a041447.'
  mla: 'Lucek, Kay, et al. “The Impact of Chromosomal Rearrangements in Speciation:
    From Micro- to Macroevolution.” <i>Cold Spring Harbor Perspectives in Biology</i>,
    vol. 15, no. 11, a041447, Cold Spring Harbor Laboratory Press, 2023, doi:<a href="https://doi.org/10.1101/cshperspect.a041447">10.1101/cshperspect.a041447</a>.'
  short: K. Lucek, M.D. Giménez, M. Joron, M. Rafajlović, J.B. Searle, N. Walden,
    A.M. Westram, R. Faria, Cold Spring Harbor Perspectives in Biology 15 (2023).
date_created: 2024-01-08T12:43:48Z
date_published: 2023-11-01T00:00:00Z
date_updated: 2026-06-18T17:37:44Z
day: '01'
ddc:
- '570'
department:
- _id: NiBa
- _id: BeVi
doi: 10.1101/cshperspect.a041447
external_id:
  isi:
  - '001096272600001'
  pmid:
  - '37604585'
intvolume: '        15'
isi: 1
issue: '11'
keyword:
- General Biochemistry
- Genetics and Molecular Biology
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1101/cshperspect.a041447
month: '11'
oa: 1
oa_version: Published Version
pmid: 1
publication: Cold Spring Harbor Perspectives in Biology
publication_identifier:
  issn:
  - 1943-0264
publication_status: published
publisher: Cold Spring Harbor Laboratory Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'The impact of chromosomal rearrangements in speciation: From micro- to macroevolution'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 15
year: '2023'
...