---
res:
  bibo_abstract:
  - Germ granules, condensates of phase-separated RNA and protein, are organelles
    that are essential for germline development in different organisms. The patterning
    of the granules and their relevance for germ cell fate are not fully understood.
    Combining three-dimensional in vivo structural and functional analyses, we study
    the dynamic spatial organization of molecules within zebrafish germ granules.
    We find that the localization of RNA molecules to the periphery of the granules,
    where ribosomes are localized, depends on translational activity at this location.
    In addition, we find that the vertebrate-specific Dead end (Dnd1) protein is essential
    for nanos3 RNA localization at the condensates’ periphery. Accordingly, in the
    absence of Dnd1, or when translation is inhibited, nanos3 RNA translocates into
    the granule interior, away from the ribosomes, a process that is correlated with
    the loss of germ cell fate. These findings highlight the relevance of sub-granule
    compartmentalization for post-transcriptional control and its importance for preserving
    germ cell totipotency.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Kim Joana
      foaf_name: Westerich, Kim Joana
      foaf_surname: Westerich
  - foaf_Person:
      foaf_givenName: Katsiaryna
      foaf_name: Tarbashevich, Katsiaryna
      foaf_surname: Tarbashevich
  - foaf_Person:
      foaf_givenName: Jan
      foaf_name: Schick, Jan
      foaf_surname: Schick
  - foaf_Person:
      foaf_givenName: Antra
      foaf_name: Gupta, Antra
      foaf_surname: Gupta
  - foaf_Person:
      foaf_givenName: Mingzhao
      foaf_name: Zhu, Mingzhao
      foaf_surname: Zhu
  - foaf_Person:
      foaf_givenName: Kenneth
      foaf_name: Hull, Kenneth
      foaf_surname: Hull
  - foaf_Person:
      foaf_givenName: Daniel
      foaf_name: Romo, Daniel
      foaf_surname: Romo
  - foaf_Person:
      foaf_givenName: Dagmar
      foaf_name: Zeuschner, Dagmar
      foaf_surname: Zeuschner
  - foaf_Person:
      foaf_givenName: Mohammad
      foaf_name: Goudarzi, Mohammad
      foaf_surname: Goudarzi
      foaf_workInfoHomepage: http://www.librecat.org/personId=3384113A-F248-11E8-B48F-1D18A9856A87
  - foaf_Person:
      foaf_givenName: Theresa
      foaf_name: Gross-Thebing, Theresa
      foaf_surname: Gross-Thebing
  - foaf_Person:
      foaf_givenName: Erez
      foaf_name: Raz, Erez
      foaf_surname: Raz
  bibo_doi: 10.1016/j.devcel.2023.06.009
  bibo_issue: '17'
  bibo_volume: 58
  dct_date: 2023^xs_gYear
  dct_isPartOf:
  - http://id.crossref.org/issn/1534-5807
  dct_language: eng
  dct_publisher: Elsevier@
  dct_subject:
  - Developmental Biology
  - Cell Biology
  - General Biochemistry
  - Genetics and Molecular Biology
  - Molecular Biology
  dct_title: Spatial organization and function of RNA molecules within phase-separated
    condensates in zebrafish are controlled by Dnd1@
  fabio_hasPubmedId: '37463577'
...