---
res:
  bibo_abstract:
  - The actin cortex is a complex cytoskeletal machinery that drives and responds
    to changes in cell shape. It must generate or adapt to plasma membrane curvature
    to facilitate diverse functions such as cell division, migration, and phagocytosis.
    Due to the complex molecular makeup of the actin cortex, it remains unclear whether
    actin networks are inherently able to sense and generate membrane curvature, or
    whether they rely on their diverse binding partners to accomplish this. Here,
    we show that curvature sensing is an inherent capability of branched actin networks
    nucleated by Arp2/3 and VCA. We develop a robust method to encapsulate actin inside
    giant unilamellar vesicles (GUVs) and assemble an actin cortex at the inner surface
    of the GUV membrane. We show that actin forms a uniform and thin cortical layer
    when present at high concentration and distinct patches associated with negative
    membrane curvature at low concentration. Serendipitously, we find that the GUV
    production method also produces dumbbell-shaped GUVs, which we explain using mathematical
    modeling in terms of membrane hemifusion of nested GUVs. We find that branched
    actin networks preferentially assemble at the neck of the dumbbells, which possess
    a micrometer-range convex curvature comparable with the curvature of the actin
    patches found in spherical GUVs. Minimal branched actin networks can thus sense
    membrane curvature, which may help mammalian cells to robustly recruit actin to
    curved membranes to facilitate diverse cellular functions such as cytokinesis
    and migration.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Lucia
      foaf_name: Baldauf, Lucia
      foaf_surname: Baldauf
  - foaf_Person:
      foaf_givenName: Felix F
      foaf_name: Frey, Felix F
      foaf_surname: Frey
      foaf_workInfoHomepage: http://www.librecat.org/personId=a0270b37-8f1a-11ec-95c7-8e710c59a4f3
  - foaf_Person:
      foaf_givenName: Marcos
      foaf_name: Arribas Perez, Marcos
      foaf_surname: Arribas Perez
  - foaf_Person:
      foaf_givenName: Timon
      foaf_name: Idema, Timon
      foaf_surname: Idema
  - foaf_Person:
      foaf_givenName: Gijsje H.
      foaf_name: Koenderink, Gijsje H.
      foaf_surname: Koenderink
  bibo_doi: 10.1016/j.bpj.2023.02.018
  bibo_issue: '11'
  bibo_volume: 122
  dct_date: 2023^xs_gYear
  dct_identifier:
  - UT:001016792600001
  dct_isPartOf:
  - http://id.crossref.org/issn/0006-3495
  dct_language: eng
  dct_publisher: Elsevier@
  dct_subject:
  - Biophysics
  dct_title: Branched actin cortices reconstituted in vesicles sense membrane curvature@
  fabio_hasPubmedId: '36806830'
...