{"external_id":{"isi":["001054596800007"],"pmid":["37624890"]},"publisher":"American Association for the Advancement of Science","license":"https://creativecommons.org/licenses/by/4.0/","publication_status":"published","month":"08","date_created":"2024-01-10T09:48:01Z","issue":"34","publication":"Science Advances","type":"journal_article","date_updated":"2024-01-16T09:38:58Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","doi":"10.1126/sciadv.adg1610","department":[{"_id":"FlSc"}],"oa_version":"Published Version","acknowledgement":"This work was supported by a postdoctoral fellowship from the Swedish Society for Medical Research to J.R., a CAPES-STINT joint grant to R.G.G. and L.S.W., a PhD fellowship from Karolinska Institutet (KID) to E.D., a PhD fellowship from Fundação para a Ciência e a Tecnologia and European Social Fund to M.M.S.O., the program of fundamental research (theme 65.1) of the Institute for Biomedical Problems of the Russian Academy of Sciences (IBMP RAS) to A.A.S., S.M.S., V.A.S., O.V.K., D.D.V., K.D.O., M.P.R., and S.A.P., the Tamkeen under the NYU Abu Dhabi Research Institute Award to the NYUAD Center for Genomics and Systems Biology (ADHPG-CGSB) to P.P., the Knut and Alice Wallenberg foundation to C.K., the Swedish National Space Agency to N.V.K. and L.S.W., Swedish Research Council, Gösta Fraenckel Foundation, and Karolinska Institutet to L.S.W.","file_date_updated":"2024-01-16T09:35:28Z","file":[{"relation":"main_file","file_id":"14809","content_type":"application/pdf","file_name":"2023_ScienceAdvances_GallardoDodd.pdf","checksum":"b9072e20e2d5d9d34d2c53319bafee41","date_created":"2024-01-16T09:35:28Z","file_size":1596639,"success":1,"date_updated":"2024-01-16T09:35:28Z","creator":"dernst","access_level":"open_access"}],"_id":"14784","article_type":"original","status":"public","keyword":["Multidisciplinary"],"year":"2023","abstract":[{"text":"The next steps of deep space exploration are manned missions to Moon and Mars. For safe space missions for crew members, it is important to understand the impact of space flight on the immune system. We studied the effects of 21 days dry immersion (DI) exposure on the transcriptomes of T cells isolated from blood samples of eight healthy volunteers. Samples were collected 7 days before DI, at day 7, 14, and 21 during DI, and 7 days after DI. RNA sequencing of CD3+T cells revealed transcriptional alterations across all time points, with most changes occurring 14 days after DI exposure. At day 21, T cells showed evidence of adaptation with a transcriptional profile resembling that of 7 days before DI. At 7 days after DI, T cells again changed their transcriptional profile. These data suggest that T cells adapt by rewiring their transcriptomes in response to simulated weightlessness and that remodeling cues persist when reexposed to normal gravity.","lang":"eng"}],"oa":1,"isi":1,"author":[{"last_name":"Gallardo-Dodd","first_name":"Carlos J.","full_name":"Gallardo-Dodd, Carlos J."},{"full_name":"Oertlin, Christian","first_name":"Christian","last_name":"Oertlin"},{"full_name":"Record, Julien","first_name":"Julien","last_name":"Record"},{"first_name":"Rômulo G.","last_name":"Galvani","full_name":"Galvani, Rômulo G."},{"last_name":"Sommerauer","first_name":"Christian","full_name":"Sommerauer, Christian"},{"full_name":"Kuznetsov, Nikolai V.","first_name":"Nikolai V.","last_name":"Kuznetsov"},{"full_name":"Doukoumopoulos, Evangelos","last_name":"Doukoumopoulos","first_name":"Evangelos"},{"last_name":"Ali","first_name":"Liaqat","full_name":"Ali, Liaqat"},{"full_name":"Oliveira, Mariana M. S.","last_name":"Oliveira","first_name":"Mariana M. S."},{"last_name":"Seitz","first_name":"Christina","full_name":"Seitz, Christina"},{"id":"45adb726-eb97-11eb-a6c2-c7c3d3caabe9","full_name":"Percipalle, Mathias","last_name":"Percipalle","first_name":"Mathias"},{"last_name":"Nikić","first_name":"Tijana","full_name":"Nikić, Tijana"},{"full_name":"Sadova, Anastasia A.","last_name":"Sadova","first_name":"Anastasia A."},{"full_name":"Shulgina, Sofia M.","first_name":"Sofia M.","last_name":"Shulgina"},{"first_name":"Vjacheslav A.","last_name":"Shmarov","full_name":"Shmarov, Vjacheslav A."},{"first_name":"Olga V.","last_name":"Kutko","full_name":"Kutko, Olga V."},{"full_name":"Vlasova, Daria D.","first_name":"Daria D.","last_name":"Vlasova"},{"first_name":"Kseniya D.","last_name":"Orlova","full_name":"Orlova, Kseniya D."},{"full_name":"Rykova, Marina P.","first_name":"Marina P.","last_name":"Rykova"},{"first_name":"John","last_name":"Andersson","full_name":"Andersson, John"},{"full_name":"Percipalle, Piergiorgio","last_name":"Percipalle","first_name":"Piergiorgio"},{"first_name":"Claudia","last_name":"Kutter","full_name":"Kutter, Claudia"},{"last_name":"Ponomarev","first_name":"Sergey A.","full_name":"Ponomarev, Sergey A."},{"full_name":"Westerberg, Lisa S.","last_name":"Westerberg","first_name":"Lisa S."}],"day":"25","language":[{"iso":"eng"}],"article_number":"adg1610","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png"},"has_accepted_license":"1","publication_identifier":{"issn":["2375-2548"]},"ddc":["570"],"citation":{"ieee":"C. J. Gallardo-Dodd <i>et al.</i>, “Exposure of volunteers to microgravity by dry immersion bed over 21 days results in gene expression changes and adaptation of T cells,” <i>Science Advances</i>, vol. 9, no. 34. American Association for the Advancement of Science, 2023.","apa":"Gallardo-Dodd, C. J., Oertlin, C., Record, J., Galvani, R. G., Sommerauer, C., Kuznetsov, N. V., … Westerberg, L. S. (2023). Exposure of volunteers to microgravity by dry immersion bed over 21 days results in gene expression changes and adaptation of T cells. <i>Science Advances</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/sciadv.adg1610\">https://doi.org/10.1126/sciadv.adg1610</a>","chicago":"Gallardo-Dodd, Carlos J., Christian Oertlin, Julien Record, Rômulo G. Galvani, Christian Sommerauer, Nikolai V. Kuznetsov, Evangelos Doukoumopoulos, et al. “Exposure of Volunteers to Microgravity by Dry Immersion Bed over 21 Days Results in Gene Expression Changes and Adaptation of T Cells.” <i>Science Advances</i>. American Association for the Advancement of Science, 2023. <a href=\"https://doi.org/10.1126/sciadv.adg1610\">https://doi.org/10.1126/sciadv.adg1610</a>.","ama":"Gallardo-Dodd CJ, Oertlin C, Record J, et al. Exposure of volunteers to microgravity by dry immersion bed over 21 days results in gene expression changes and adaptation of T cells. <i>Science Advances</i>. 2023;9(34). doi:<a href=\"https://doi.org/10.1126/sciadv.adg1610\">10.1126/sciadv.adg1610</a>","short":"C.J. Gallardo-Dodd, C. Oertlin, J. Record, R.G. Galvani, C. Sommerauer, N.V. Kuznetsov, E. Doukoumopoulos, L. Ali, M.M.S. Oliveira, C. Seitz, M. Percipalle, T. Nikić, A.A. Sadova, S.M. Shulgina, V.A. Shmarov, O.V. Kutko, D.D. Vlasova, K.D. Orlova, M.P. Rykova, J. Andersson, P. Percipalle, C. Kutter, S.A. Ponomarev, L.S. Westerberg, Science Advances 9 (2023).","mla":"Gallardo-Dodd, Carlos J., et al. “Exposure of Volunteers to Microgravity by Dry Immersion Bed over 21 Days Results in Gene Expression Changes and Adaptation of T Cells.” <i>Science Advances</i>, vol. 9, no. 34, adg1610, American Association for the Advancement of Science, 2023, doi:<a href=\"https://doi.org/10.1126/sciadv.adg1610\">10.1126/sciadv.adg1610</a>.","ista":"Gallardo-Dodd CJ, Oertlin C, Record J, Galvani RG, Sommerauer C, Kuznetsov NV, Doukoumopoulos E, Ali L, Oliveira MMS, Seitz C, Percipalle M, Nikić T, Sadova AA, Shulgina SM, Shmarov VA, Kutko OV, Vlasova DD, Orlova KD, Rykova MP, Andersson J, Percipalle P, Kutter C, Ponomarev SA, Westerberg LS. 2023. Exposure of volunteers to microgravity by dry immersion bed over 21 days results in gene expression changes and adaptation of T cells. Science Advances. 9(34), adg1610."},"intvolume":"         9","title":"Exposure of volunteers to microgravity by dry immersion bed over 21 days results in gene expression changes and adaptation of T cells","article_processing_charge":"Yes","pmid":1,"volume":9,"date_published":"2023-08-25T00:00:00Z","quality_controlled":"1"}