---
res:
  bibo_abstract:
  - Understanding the phenotypic and genetic architecture of reproductive isolation
    is a long‐standing goal of speciation research. In several systems, large‐effect
    loci contributing to barrier phenotypes have been characterized, but such causal
    connections are rarely known for more complex genetic architectures. In this study,
    we combine “top‐down” and “bottom‐up” approaches with demographic modelling toward
    an integrated understanding of speciation across a monkeyflower hybrid zone. Previous
    work suggests that pollinator visitation acts as a primary barrier to gene flow
    between two divergent red‐ and yellow‐flowered ecotypes of<jats:italic>Mimulus
    aurantiacus</jats:italic>. Several candidate isolating traits and anonymous single
    nucleotide polymorphism loci under divergent selection have been identified, but
    their genomic positions remain unknown. Here, we report findings from demographic
    analyses that indicate this hybrid zone formed by secondary contact, but that
    subsequent gene flow was restricted by widespread barrier loci across the genome.
    Using a novel, geographic cline‐based genome scan, we demonstrate that candidate
    barrier loci are broadly distributed across the genome, rather than mapping to
    one or a few “islands of speciation.” Quantitative trait locus (QTL) mapping reveals
    that most floral traits are highly polygenic, with little evidence that QTL colocalize,
    indicating that most traits are genetically independent. Finally, we find little
    evidence that QTL and candidate barrier loci overlap, suggesting that some loci
    contribute to other forms of reproductive isolation. Our findings highlight the
    challenges of understanding the genetic architecture of reproductive isolation
    and reveal that barriers to gene flow other than pollinator isolation may play
    an important role in this system.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Sean
      foaf_name: Stankowski, Sean
      foaf_surname: Stankowski
      foaf_workInfoHomepage: http://www.librecat.org/personId=43161670-5719-11EA-8025-FABC3DDC885E
  - foaf_Person:
      foaf_givenName: Madeline A.
      foaf_name: Chase, Madeline A.
      foaf_surname: Chase
  - foaf_Person:
      foaf_givenName: Hanna
      foaf_name: McIntosh, Hanna
      foaf_surname: McIntosh
  - foaf_Person:
      foaf_givenName: Matthew A.
      foaf_name: Streisfeld, Matthew A.
      foaf_surname: Streisfeld
  bibo_doi: 10.1111/mec.16849
  bibo_issue: '8'
  bibo_volume: 32
  dct_date: 2023^xs_gYear
  dct_identifier:
  - UT:000919244600001
  dct_isPartOf:
  - http://id.crossref.org/issn/0962-1083
  - http://id.crossref.org/issn/1365-294X
  dct_language: eng
  dct_publisher: Wiley@
  dct_subject:
  - Genetics
  - Ecology
  - Evolution
  - Behavior and Systematics
  dct_title: Integrating top‐down and bottom‐up approaches to understand the genetic
    architecture of speciation across a monkeyflower hybrid zone@
  fabio_hasPubmedId: '36651268'
...