---
res:
  bibo_abstract:
  - Understanding complex living systems, which are fundamentally constrained by physical
    phenomena, requires combining experimental data with theoretical physical and
    mathematical models. To develop such models, collaborations between experimental
    cell biologists and theoreticians are increasingly important but these two groups
    often face challenges achieving mutual understanding. To help navigate these challenges,
    this Perspective discusses different modelling approaches, including bottom-up
    hypothesis-driven and top-down data-driven models, and highlights their strengths
    and applications. Using cell mechanics as an example, we explore the integration
    of specific physical models with experimental data from the molecular, cellular
    and tissue level up to multiscale input. We also emphasize the importance of constraining
    model complexity and outline strategies for crosstalk between experimental design
    and model development. Furthermore, we highlight how physical models can provide
    conceptual insights and produce unifying and generalizable frameworks for biological
    phenomena. Overall, this Perspective aims to promote fruitful collaborations that
    advance our understanding of complex biological systems.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Cornelia
      foaf_name: Schwayer, Cornelia
      foaf_surname: Schwayer
      foaf_workInfoHomepage: http://www.librecat.org/personId=3436488C-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0001-5130-2226
  - foaf_Person:
      foaf_givenName: David
      foaf_name: Brückner, David
      foaf_surname: Brückner
      foaf_workInfoHomepage: http://www.librecat.org/personId=e1e86031-6537-11eb-953a-f7ab92be508d
    orcid: 0000-0001-7205-2975
  bibo_doi: 10.1242/jcs.261515
  bibo_issue: '24'
  bibo_volume: 136
  dct_date: 2023^xs_gYear
  dct_identifier:
  - UT:001165394900011
  dct_isPartOf:
  - http://id.crossref.org/issn/0021-9533
  - http://id.crossref.org/issn/1477-9137
  dct_language: eng
  dct_publisher: The Company of Biologists@
  dct_subject:
  - Cell Biology
  dct_title: Connecting theory and experiment in cell and tissue mechanics@
  fabio_hasPubmedId: '38149871'
...