{"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa":1,"date_updated":"2024-07-16T12:15:42Z","title":"Dynamic and selective engrams emerge with memory consolidation","ddc":["570"],"publication_identifier":{"eissn":["1546-1726"],"issn":["1097-6256"]},"has_accepted_license":"1","file_date_updated":"2024-07-16T12:15:19Z","file":[{"file_size":15830346,"file_name":"2024_NatureNeuroscience_FeitosaTome.pdf","success":1,"file_id":"17268","relation":"main_file","creator":"dernst","date_updated":"2024-07-16T12:15:19Z","date_created":"2024-07-16T12:15:19Z","access_level":"open_access","checksum":"c509fcad757e4c1c153e857e55c20083","content_type":"application/pdf"}],"publication_status":"published","doi":"10.1038/s41593-023-01551-w","external_id":{"isi":["001145442300001"]},"publication":"Nature Neuroscience","isi":1,"department":[{"_id":"TiVo"}],"author":[{"full_name":"Feitosa Tomé, Douglas","last_name":"Feitosa Tomé","first_name":"Douglas","id":"0eed2d40-3d48-11ec-8d38-f789cc2e40b2"},{"last_name":"Zhang","full_name":"Zhang, Ying","first_name":"Ying"},{"last_name":"Aida","full_name":"Aida, Tomomi","first_name":"Tomomi"},{"last_name":"Mosto","full_name":"Mosto, Olivia","first_name":"Olivia"},{"full_name":"Lu, Yifeng","last_name":"Lu","first_name":"Yifeng"},{"first_name":"Mandy","full_name":"Chen, Mandy","last_name":"Chen"},{"full_name":"Sadeh, Sadra","last_name":"Sadeh","first_name":"Sadra"},{"first_name":"Dheeraj S.","full_name":"Roy, Dheeraj S.","last_name":"Roy"},{"first_name":"Claudia","last_name":"Clopath","full_name":"Clopath, Claudia"}],"date_created":"2024-01-28T23:01:43Z","month":"03","related_material":{"record":[{"status":"public","id":"14892","relation":"research_data"}]},"abstract":[{"text":"Episodic memories are encoded by experience-activated neuronal ensembles that remain necessary and sufficient for recall. However, the temporal evolution of memory engrams after initial encoding is unclear. In this study, we employed computational and experimental approaches to examine how the neural composition and selectivity of engrams change with memory consolidation. Our spiking neural network model yielded testable predictions: memories transition from unselective to selective as neurons drop out of and drop into engrams; inhibitory activity during recall is essential for memory selectivity; and inhibitory synaptic plasticity during memory consolidation is critical for engrams to become selective. Using activity-dependent labeling, longitudinal calcium imaging and a combination of optogenetic and chemogenetic manipulations in mouse dentate gyrus, we conducted contextual fear conditioning experiments that supported our model’s predictions. Our results reveal that memory engrams are dynamic and that changes in engram composition mediated by inhibitory plasticity are crucial for the emergence of memory selectivity.","lang":"eng"}],"article_type":"original","citation":{"chicago":"Feitosa Tomé, Douglas, Ying Zhang, Tomomi Aida, Olivia Mosto, Yifeng Lu, Mandy Chen, Sadra Sadeh, Dheeraj S. Roy, and Claudia Clopath. “Dynamic and Selective Engrams Emerge with Memory Consolidation.” <i>Nature Neuroscience</i>. Springer Nature, 2024. <a href=\"https://doi.org/10.1038/s41593-023-01551-w\">https://doi.org/10.1038/s41593-023-01551-w</a>.","apa":"Feitosa Tomé, D., Zhang, Y., Aida, T., Mosto, O., Lu, Y., Chen, M., … Clopath, C. (2024). Dynamic and selective engrams emerge with memory consolidation. <i>Nature Neuroscience</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41593-023-01551-w\">https://doi.org/10.1038/s41593-023-01551-w</a>","short":"D. Feitosa Tomé, Y. Zhang, T. Aida, O. Mosto, Y. Lu, M. Chen, S. Sadeh, D.S. Roy, C. Clopath, Nature Neuroscience 27 (2024) 561–572.","ista":"Feitosa Tomé D, Zhang Y, Aida T, Mosto O, Lu Y, Chen M, Sadeh S, Roy DS, Clopath C. 2024. Dynamic and selective engrams emerge with memory consolidation. Nature Neuroscience. 27, 561–572.","mla":"Feitosa Tomé, Douglas, et al. “Dynamic and Selective Engrams Emerge with Memory Consolidation.” <i>Nature Neuroscience</i>, vol. 27, Springer Nature, 2024, pp. 561–72, doi:<a href=\"https://doi.org/10.1038/s41593-023-01551-w\">10.1038/s41593-023-01551-w</a>.","ieee":"D. Feitosa Tomé <i>et al.</i>, “Dynamic and selective engrams emerge with memory consolidation,” <i>Nature Neuroscience</i>, vol. 27. Springer Nature, pp. 561–572, 2024.","ama":"Feitosa Tomé D, Zhang Y, Aida T, et al. Dynamic and selective engrams emerge with memory consolidation. <i>Nature Neuroscience</i>. 2024;27:561-572. doi:<a href=\"https://doi.org/10.1038/s41593-023-01551-w\">10.1038/s41593-023-01551-w</a>"},"type":"journal_article","volume":27,"article_processing_charge":"Yes (in subscription journal)","status":"public","oa_version":"Published Version","date_published":"2024-03-01T00:00:00Z","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)"},"_id":"14887","scopus_import":"1","language":[{"iso":"eng"}],"quality_controlled":"1","year":"2024","acknowledgement":"We thank S. Erisken from Inscopix for helping us establish in vivo one-photon calcium imaging for this work. We thank K. Su at Tsinghua University for assistance with this work. This work was funded by the President’s PhD Scholarship from Imperial College London (D.F.T.), the Wellcome Trust (225412/Z/22/Z) (S.S.), the Biotechnology and Biological Sciences Research Council (BB/N013956/1 and BB/N019008/1) (C.C.), the Wellcome Trust (200790/Z/16/Z) (C.C.), the Simons Foundation (564408) (C.C.) and the Engineering and Physical Sciences Research Council (EP/R035806/1) (CC). The School of Life Sciences and the IDG/McGovern Institute for Brain Research supported Y.Z. The Warren Alpert Distinguished Scholar Award and National Institutes of Health 1K99NS125131-01 supported D.S.R.","intvolume":"        27","page":"561-572","publisher":"Springer Nature","day":"01"}