---
res:
  bibo_abstract:
  - A short, 14-amino-acid segment called SP1, located in the Gag structural protein1,
    has a critical role during the formation of the HIV-1 virus particle. During virus
    assembly, the SP1 peptide and seven preceding residues fold into a six-helix bundle,
    which holds together the Gag hexamer and facilitates the formation of a curved
    immature hexagonal lattice underneath the viral membrane2,3. Upon completion of
    assembly and budding, proteolytic cleavage of Gag leads to virus maturation, in
    which the immature lattice is broken down; the liberated CA domain of Gag then
    re-assembles into the mature conical capsid that encloses the viral genome and
    associated enzymes. Folding and proteolysis of the six-helix bundle are crucial
    rate-limiting steps of both Gag assembly and disassembly, and the six-helix bundle
    is an established target of HIV-1 inhibitors4,5. Here, using a combination of
    structural and functional analyses, we show that inositol hexakisphosphate (InsP6,
    also known as IP6) facilitates the formation of the six-helix bundle and assembly
    of the immature HIV-1 Gag lattice. IP6 makes ionic contacts with two rings of
    lysine residues at the centre of the Gag hexamer. Proteolytic cleavage then unmasks
    an alternative binding site, where IP6 interaction promotes the assembly of the
    mature capsid lattice. These studies identify IP6 as a naturally occurring small
    molecule that promotes both assembly and maturation of HIV-1.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Robert
      foaf_name: Dick, Robert
      foaf_surname: Dick
  - foaf_Person:
      foaf_givenName: Kaneil K
      foaf_name: Zadrozny, Kaneil K
      foaf_surname: Zadrozny
  - foaf_Person:
      foaf_givenName: Chaoyi
      foaf_name: Xu, Chaoyi
      foaf_surname: Xu
  - foaf_Person:
      foaf_givenName: Florian
      foaf_name: Schur, Florian
      foaf_surname: Schur
      foaf_workInfoHomepage: http://www.librecat.org/personId=48AD8942-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0003-4790-8078
  - foaf_Person:
      foaf_givenName: Terri D
      foaf_name: Lyddon, Terri D
      foaf_surname: Lyddon
  - foaf_Person:
      foaf_givenName: Clifton L
      foaf_name: Ricana, Clifton L
      foaf_surname: Ricana
  - foaf_Person:
      foaf_givenName: Jonathan M
      foaf_name: Wagner, Jonathan M
      foaf_surname: Wagner
  - foaf_Person:
      foaf_givenName: Juan R
      foaf_name: Perilla, Juan R
      foaf_surname: Perilla
  - foaf_Person:
      foaf_givenName: Pornillos Barbie K
      foaf_name: Ganser, Pornillos Barbie K
      foaf_surname: Ganser
  - foaf_Person:
      foaf_givenName: Marc C
      foaf_name: Johnson, Marc C
      foaf_surname: Johnson
  - foaf_Person:
      foaf_givenName: Owen
      foaf_name: Pornillos, Owen
      foaf_surname: Pornillos
  - foaf_Person:
      foaf_givenName: Volker
      foaf_name: Vogt, Volker
      foaf_surname: Vogt
  bibo_doi: 10.1038/s41586-018-0396-4
  bibo_issue: '7719'
  bibo_volume: 560
  dct_date: 2018^xs_gYear
  dct_identifier:
  - UT:000442483400046
  dct_isPartOf:
  - http://id.crossref.org/issn/1476-4687
  dct_language: eng
  dct_publisher: Nature Publishing Group@
  dct_title: Inositol phosphates are assembly co-factors for HIV-1@
  fabio_hasPubmedId: '30158708'
...