---
res:
  bibo_abstract:
  - The GNOM (GN) Guanine nucleotide Exchange Factor for ARF small GTPases (ARF-GEF)
    is among the best studied trafficking regulators in plants, playing crucial and
    unique developmental roles in patterning and polarity. The current models place
    GN at the Golgi apparatus (GA), where it mediates secretion/recycling, and at
    the plasma membrane (PM) presumably contributing to clathrin-mediated endocytosis
    (CME). The mechanistic basis of the developmental function of GN, distinct from
    the other ARF-GEFs including its closest homologue GNOM-LIKE1 (GNL1), remains
    elusive. Insights from this study largely extend the current notions of GN function.
    We show that GN, but not GNL1, localizes to the cell periphery at long-lived structures
    distinct from clathrin-coated pits, while CME and secretion proceed normally in
    <jats:italic>gn</jats:italic> knockouts. The functional GN mutant variant GN<jats:sup>fewerroots</jats:sup>,
    absent from the GA, suggests that the cell periphery is the major site of GN action
    responsible for its developmental function. Following inhibition by Brefeldin
    A, GN, but not GNL1, relocates to the PM likely on exocytic vesicles, suggesting
    selective molecular associations en route to the cell periphery. A study of GN-GNL1
    chimeric ARF-GEFs indicates that all GN domains contribute to the specific GN
    function in a partially redundant manner. Together, this study offers significant
    steps toward the elucidation of the mechanism underlying unique cellular and development
    functions of GNOM.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Maciek
      foaf_name: Adamowski, Maciek
      foaf_surname: Adamowski
      foaf_workInfoHomepage: http://www.librecat.org/personId=45F536D2-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0001-6463-5257
  - foaf_Person:
      foaf_givenName: Ivana
      foaf_name: Matijevic, Ivana
      foaf_surname: Matijevic
      foaf_workInfoHomepage: http://www.librecat.org/personId=83c17ce3-15b2-11ec-abd3-f486545870bd
  - foaf_Person:
      foaf_givenName: Jiří
      foaf_name: Friml, Jiří
      foaf_surname: Friml
      foaf_workInfoHomepage: http://www.librecat.org/personId=4159519E-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0002-8302-7596
  bibo_doi: 10.7554/elife.68993
  bibo_volume: 13
  dct_date: 2024^xs_gYear
  dct_identifier:
  - UT:001174278000001
  dct_isPartOf:
  - http://id.crossref.org/issn/2050-084X
  dct_language: eng
  dct_publisher: eLife Sciences Publications@
  dct_subject:
  - General Immunology and Microbiology
  - General Biochemistry
  - Genetics and Molecular Biology
  - General Medicine
  - General Neuroscience
  dct_title: Developmental patterning function of GNOM ARF-GEF mediated from the cell
    periphery@
  fabio_hasPubmedId: '38381485'
...