---
res:
  bibo_abstract:
  - Embryogenesis results from the coordinated activities of different signaling pathways
    controlling cell fate specification and morphogenesis. In vertebrate gastrulation,
    both Nodal and BMP signaling play key roles in germ layer specification and morphogenesis,
    yet their interplay to coordinate embryo patterning with morphogenesis is still
    insufficiently understood. Here, we took a reductionist approach using zebrafish
    embryonic explants to study the coordination of Nodal and BMP signaling for embryo
    patterning and morphogenesis. We show that Nodal signaling triggers explant elongation
    by inducing mesendodermal progenitors but also suppressing BMP signaling activity
    at the site of mesendoderm induction. Consistent with this, ectopic BMP signaling
    in the mesendoderm blocks cell alignment and oriented mesendoderm intercalations,
    key processes during explant elongation. Translating these ex vivo observations
    to the intact embryo showed that, similar to explants, Nodal signaling suppresses
    the effect of BMP signaling on cell intercalations in the dorsal domain, thus
    allowing robust embryonic axis elongation. These findings suggest a dual function
    of Nodal signaling in embryonic axis elongation by both inducing mesendoderm and
    suppressing BMP effects in the dorsal portion of the mesendoderm.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Alexandra
      foaf_name: Schauer, Alexandra
      foaf_surname: Schauer
      foaf_workInfoHomepage: http://www.librecat.org/personId=30A536BA-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0001-7659-9142
  - foaf_Person:
      foaf_givenName: Kornelija
      foaf_name: Pranjic-Ferscha, Kornelija
      foaf_surname: Pranjic-Ferscha
      foaf_workInfoHomepage: http://www.librecat.org/personId=4362B3C2-F248-11E8-B48F-1D18A9856A87
  - foaf_Person:
      foaf_givenName: Robert
      foaf_name: Hauschild, Robert
      foaf_surname: Hauschild
      foaf_workInfoHomepage: http://www.librecat.org/personId=4E01D6B4-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0001-9843-3522
  - foaf_Person:
      foaf_givenName: Carl-Philipp J
      foaf_name: Heisenberg, Carl-Philipp J
      foaf_surname: Heisenberg
      foaf_workInfoHomepage: http://www.librecat.org/personId=39427864-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0002-0912-4566
  bibo_doi: 10.1242/dev.202316
  bibo_issue: '4'
  bibo_volume: 151
  dct_date: 2024^xs_gYear
  dct_identifier:
  - UT:001170580200001
  dct_isPartOf:
  - http://id.crossref.org/issn/0950-1991
  - http://id.crossref.org/issn/1477-9129
  dct_language: eng
  dct_publisher: The Company of Biologists@
  dct_title: Robust axis elongation by Nodal-dependent restriction of BMP signaling@
  fabio_hasPubmedId: '38372390'
...