---
res:
  bibo_abstract:
  - Vaccinia virus–related kinase (VRK) is an evolutionarily conserved nuclear protein
    kinase. VRK-1, the single Caenorhabditis elegans VRK ortholog, functions in cell
    division and germline proliferation. However, the role of VRK-1 in postmitotic
    cells and adult life span remains unknown. Here, we show that VRK-1 increases
    organismal longevity by activating the cellular energy sensor, AMP-activated protein
    kinase (AMPK), via direct phosphorylation. We found that overexpression of vrk-1
    in the soma of adult C. elegans increased life span and, conversely, inhibition
    of vrk-1 decreased life span. In addition, vrk-1 was required for longevity conferred
    by mutations that inhibit C. elegans mitochondrial respiration, which requires
    AMPK. VRK-1 directly phosphorylated and up-regulated AMPK in both C. elegans and
    cultured human cells. Thus, our data show that the somatic nuclear kinase, VRK-1,
    promotes longevity through AMPK activation, and this function appears to be conserved
    between C. elegans and humans.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Sangsoon
      foaf_name: Park, Sangsoon
      foaf_surname: Park
  - foaf_Person:
      foaf_givenName: Murat
      foaf_name: Artan, Murat
      foaf_surname: Artan
      foaf_workInfoHomepage: http://www.librecat.org/personId=C407B586-6052-11E9-B3AE-7006E6697425
    orcid: 0000-0001-8945-6992
  - foaf_Person:
      foaf_givenName: Seung Hyun
      foaf_name: Han, Seung Hyun
      foaf_surname: Han
  - foaf_Person:
      foaf_givenName: Hae-Eun H.
      foaf_name: Park, Hae-Eun H.
      foaf_surname: Park
  - foaf_Person:
      foaf_givenName: Yoonji
      foaf_name: Jung, Yoonji
      foaf_surname: Jung
  - foaf_Person:
      foaf_givenName: Ara B.
      foaf_name: Hwang, Ara B.
      foaf_surname: Hwang
  - foaf_Person:
      foaf_givenName: Won Sik
      foaf_name: Shin, Won Sik
      foaf_surname: Shin
  - foaf_Person:
      foaf_givenName: Kyong-Tai
      foaf_name: Kim, Kyong-Tai
      foaf_surname: Kim
  - foaf_Person:
      foaf_givenName: Seung-Jae V.
      foaf_name: Lee, Seung-Jae V.
      foaf_surname: Lee
  bibo_doi: 10.1126/sciadv.aaw7824
  bibo_issue: '27'
  bibo_volume: 6
  dct_date: 2020^xs_gYear
  dct_isPartOf:
  - http://id.crossref.org/issn/2375-2548
  dct_language: eng
  dct_publisher: American Association for the Advancement of Science@
  dct_title: VRK-1 extends life span by activation of AMPK via phosphorylation@
...